CENPF and IRF6

		CENPF	IRF6
Description		centromere protein F	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber	Chromatin Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Cell Division Metaphase Chromosome Alignment Kinetochore Assembly DNA Biosynthetic Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Keratinocyte Differentiation Skin Development Keratinocyte Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Limb Development Mammary Gland Epithelial Cell Differentiation Stem Cell Proliferation Cranial Skeletal System Development Negative Regulation Of Stem Cell Proliferation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases			IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Lung function (FVC) ( 30061609) Response to antineoplastic agents ( 21659360) Serum immune biomarker levels ( 32066700)	Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734) Systolic blood pressure ( 30224653)
Interacting Genes		12 interacting genes: BRAP CDK1 CENPE CHMP2B FNTA FNTB KPNA1 NDEL1 NUP133 SNAP25 SVIL TOP3B	4 interacting genes: IRF8 RFX3 TLX2 ZBTB3
Entrez ID		1063	3664
HPRD ID		02582	06227
Ensembl ID		ENSG00000117724	ENSG00000117595
Uniprot IDs		A0A9L9PXU7 P49454	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Microtubule Associated Complex Protein Prenyltransferase Activity Kinetochore Midbody Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Chromosome Localization Nuclear Pore Nucleus Organization Kinetochore Microtubule Nuclear Localization Sequence Binding Nuclear Envelope Organization Microtubule Cytoskeleton Organization Involved In Mitosis Organelle Fusion Chromosome Organization Chromosome Segregation Cytosol Organelle Organization Pronuclear Fusion Chromosome, Centromeric Region Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Metaphase Chromosome Alignment Peptide Pheromone Maturation Alpha-tubulin Binding Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Glutamatergic Postsynaptic Density Negative Regulation Of Zinc Ion Transmembrane Import RNA Topoisomerase Activity Nuclear Membrane Organization Organelle Localization Regulation Of Microtubule-based Movement Regulation Of Cellular Localization Mitotic DNA-templated DNA Replication Spindle Cyclin B1-CDK1 Complex Regulation Of Protein Localization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Metaphase Chromosome Alignment CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Hydroxylysine Biosynthetic Process Detoxification Of Zinc Ion	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Plasmacytoid Dendritic Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Development Type B Pancreatic Cell Maturation DNA Binding Plasmacytoid Dendritic Cell Activation Follicular B Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Ciliary Transition Fiber Pronucleus Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Dendrite Morphogenesis Germinal Center B Cell Differentiation Kinetochore Assembly Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Negative Regulation Of RNA Metabolic Process Kinetochore Organization Regulation Of Metabolic Process Endocrine Pancreas Development
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