CENPF and HSD11B1

Data Source: HiPPIP (Novel)

		CENPF	HSD11B1
Name		centromere protein F	hydroxysteroid 11-beta dehydrogenase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding	Steroid Binding Oxidoreductase Activity Protein Homodimerization Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity NADP Binding 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Cortisol Dehydrogenase (NADP+) Activity
	Biological Process	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Cell Division Metaphase Chromosome Alignment Kinetochore Assembly DNA Biosynthetic Process	Lipid Metabolic Process Steroid Catabolic Process Steroid Metabolic Process Lung Development
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Glucocorticoid biosynthesis Prednisone ADME
Drugs		None	NADH Carbenoxolone Nicotinamide adenine dinucleotide phosphate 2-(N-morpholino)ethanesulfonic acid Corticosterone INCB13739 (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone (5S)-2-{[(1S)-1-(4-Fluorophenyl)ethyl]amino}-5-(2-hydroxy-2-propanyl)-5-methyl-1,3-thiazol-4(5H)-one (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide (5S)-2-(Cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE (5R)-2-[(2-Fluorophenyl)amino]-5-isopropyl-1,3-thiazol-4(5H)-one Glycyrrhizic acid
Diseases		None	Cortisone reductase deficiency (CRD)
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Lung function (FVC) ( 30061609 ) Response to antineoplastic agents ( 21659360 ) Serum immune biomarker levels ( 32066700 )	Alopecia areata ( 25608926 )
Novel Interactors		6 novel interactors: HSD11B1 IRF6 KLHL41 PLOD2 SLC30A1 SLC4A1AP	1 novel interactors: CENPF
Interacting Genes		12 interacting genes: BRAP CDK1 CENPE CHMP2B FNTA FNTB KPNA1 NDEL1 NUP133 SNAP25 SVIL TOP3B	2 interacting genes: CD36 GKAP1
Entrez ID		1063	3290
HPRD ID		02582	07042
Ensembl ID		ENSG00000117724	ENSG00000117594
Uniprot IDs		A0A9L9PXU7 P49454	P28845 X5D2L1
PDB IDs		Not available	1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 4C7J 4C7K 4HFR 4HX5 4IJU 4IJV 4IJW 4K1L 4P38 4YYZ 5PGU 5PGV 5PGW 5PGX 5PGY 5QII
GO Terms Enriched among Interactors		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Microtubule Associated Complex Protein Prenyltransferase Activity Kinetochore Midbody Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Chromosome Localization Nuclear Pore Nucleus Organization Kinetochore Microtubule Nuclear Localization Sequence Binding Nuclear Envelope Organization Microtubule Cytoskeleton Organization Involved In Mitosis Organelle Fusion Chromosome Organization Chromosome Segregation Cytosol Organelle Organization Pronuclear Fusion Chromosome, Centromeric Region Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Metaphase Chromosome Alignment Peptide Pheromone Maturation Alpha-tubulin Binding Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Glutamatergic Postsynaptic Density Negative Regulation Of Zinc Ion Transmembrane Import RNA Topoisomerase Activity Nuclear Membrane Organization Organelle Localization Regulation Of Microtubule-based Movement Regulation Of Cellular Localization Mitotic DNA-templated DNA Replication Spindle Cyclin B1-CDK1 Complex Regulation Of Protein Localization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Metaphase Chromosome Alignment CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Hydroxylysine Biosynthetic Process Detoxification Of Zinc Ion	CGMP-mediated Signaling Oleate Transmembrane Transporter Activity Short-chain Fatty Acid Transport Response To Linoleic Acid Lipoteichoic Acid Immune Receptor Activity Long-chain Fatty Acid Import Across Plasma Membrane Thrombospondin Receptor Activity Short-chain Fatty Acid Transmembrane Transporter Activity Positive Regulation Of Blood Microparticle Formation Oxidised Low-density Lipoprotein Particle Receptor Activity Triglyceride Transport Low-density Lipoprotein Particle Mediated Signaling Oxidised Low-density Lipoprotein Particle Clearance Intestinal Cholesterol Absorption Response To Bacterial Lipoprotein Positive Regulation Of Cholesterol Storage Lipoprotein Particle Binding Intracellular Signal Transduction Cellular Response To Lipoteichoic Acid Regulation Of Removal Of Superoxide Radicals Regulation Of Response To Reactive Oxygen Species Response To Stilbenoid Nitric Oxide-cGMP-mediated Signaling Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cholesterol Import Intestinal Lipid Absorption Amyloid-beta Clearance By Cellular Catabolic Process Toll-like Receptor Binding Cellular Response To Hydroperoxide Long-chain Fatty Acid Import Into Cell Cellular Response To Bacterial Lipopeptide Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Phagocytosis, Engulfment Lipid Transport Across Blood-brain Barrier Cellular Response To Diacyl Bacterial Lipopeptide Lipid Import Into Cell High-density Lipoprotein Particle Binding Phagocytosis, Recognition Kinetochore Assembly Ciliary Transition Fiber Pronucleus Low-density Lipoprotein Particle Receptor Activity Low-density Lipoprotein Particle Clearance Lipoprotein Transport Low-density Lipoprotein Particle Binding Platelet Alpha Granule Membrane Long-chain Fatty Acid Transmembrane Transporter Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Kinetochore Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation