DAZAP2 and RAD18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DAZAP2	RAD18
Description		DAZ associated protein 2	RAD18 E3 ubiquitin protein ligase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Stress Granule Nuclear Body Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex
	Molecular Function	P53 Binding Transcription Coactivator Activity Protein Binding Receptor Tyrosine Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity WW Domain Binding Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding	Y-form DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Destabilization Stress Granule Assembly Positive Regulation Of DNA-templated Transcription	DNA Repair Postreplication Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Autoubiquitination Positive Regulation Of Chromosome Segregation
Pathways			Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)
Interacting Genes		168 interacting genes: AATF ACOT7 AOC1 ARID5A ATXN1 ATXN1L BAG3 BATF2 BHLHE40 C1orf94 CALCOCO2 CAMK2A CAPN15 CCDC120 CDK4 CELF5 CEP70 CLASRP COL4A2 COL4A5 CXCL12 DAB1 DAZ1 DAZL DCUN1D1 DESI1 DTX2 EPN1 EPN2 EPN3 ESRP1 EXD3 FAM168A FAM83A FBN3 FOXH1 GGA3 GPS2 GPSM1 HEY1 HGS HIP1 HIPK2 INCA1 KLHL42 KRTAP19-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 LGALS9 LITAF LMO2 MAGED1 MAPK1IP1L MED31 MINDY1 MINDY3 MTURN MYEOV MYOZ3 NDUFA5 NEDD4 NEDD4L NOC4L NOTCH1 OPTN OTUB2 OTUD7B OTULIN PATZ1 PDIK1L PEF1 PITX2 PLEKHB2 PLEKHF2 PLSCR1 PLSCR4 POGZ POLI PROP1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PRR34 RABGEF1 RAD18 RAD23A RAMAC RBFOX1 RBFOX2 RBM11 RBM24 RBM43 RBPMS RHOXF2 RNF115 RNF208 RNF44 ROR2 RPS27A RUNX1 SEPTIN2 SIAH1 SMAP2 SMURF2 SNRPC SOX10 SOX6 SPMIP9 SQSTM1 STAM2 STAT6 TAX1BP1 TBX6 TCF7L2 TENT5B TENT5C TFG TIAL1 TLE1 TLE5 TNIP1 TNIP3 TOLLIP TOM1 TP53 UBA52 UBAC1 UBAP2 UBASH3A UBASH3B UBB UBC UBE2D4 UBE2E2 UBE2E3 UBE2V1 UBE3A UBQLN1 UBQLN2 UBQLN4 UBXN6 UBXN7 USP13 USP5 VENTX VEZF1 VHLL VPS37C WDR73 WWOX WWP1 YOD1 ZBTB32 ZC3H10 ZFAND2A ZFAND2B ZFYVE9 ZNF34 ZNF581	30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 H2AC4 MAGEA4 MAP3K1 MAPK8 MLKL ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7
Entrez ID		9802	56852
HPRD ID		08463	09242
Ensembl ID		ENSG00000183283	ENSG00000070950
Uniprot IDs		Q15038	Q9NS91
PDB IDs			2MRE 2MRF 2Y43 2YBF 5VF0 8IR2 8IR4 9BD3
Enriched GO Terms of Interacting Partners?		Protein Binding Polyubiquitin Modification-dependent Protein Binding Post-translational Protein Modification Ubiquitin Binding Nucleus Protein Ubiquitination Protein Modification By Small Protein Conjugation Nucleoplasm Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Protein Catabolic Process Autophagy Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process K48-linked Deubiquitinase Activity Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Cysteine-type Deubiquitinase Activity Positive Regulation Of Metabolic Process Macroautophagy Protein K48-linked Deubiquitination Negative Regulation Of Signal Transduction Cysteine-type Peptidase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Protein Tag Activity Protein Metabolic Process Identical Protein Binding Cytosol Autophagosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Removal Clathrin Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Macroautophagy Establishment Of Protein Localization To Vacuole	Post-translational Protein Modification Protein Modification By Small Protein Conjugation DNA Repair Protein Modification Process DNA Metabolic Process Protein Ubiquitination Macromolecule Metabolic Process Postreplication Repair Protein Polyubiquitination DNA Damage Response Response To Radiation Ubiquitin Protein Ligase Binding Nucleus Nuclear Body Ubiquitin-protein Transferase Activity Protein Metabolic Process Response To UV Replication Fork Response To Light Stimulus Ubiquitin Conjugating Enzyme Activity HULC Complex Protein K48-linked Ubiquitination Regulation Of Autophagy PML Body Nucleoplasm Chromatin Organization ATP Binding Nucleotide Binding Regulation Of Metabolic Process Transferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Cellular Response To Radiation Cellular Response To Stress Positive Regulation Of Autophagy Chromosome, Telomeric Region P53 Binding Ubiquitin Protein Ligase Activity Response To Stress Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Single-stranded DNA Helicase Activity Ubiquitin-like Protein Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA Polymerase Binding
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