DAZAP2 and CXCL12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DAZAP2	CXCL12
Description		DAZ associated protein 2	C-X-C motif chemokine ligand 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Stress Granule Nuclear Body Nuclear Speck Protein-containing Complex	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	P53 Binding Transcription Coactivator Activity Protein Binding Receptor Tyrosine Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity WW Domain Binding Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding	Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Protein Destabilization Stress Granule Assembly Positive Regulation Of DNA-templated Transcription	Response To Hypoxia Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Intracellular Calcium Ion Homeostasis Chemotaxis Defense Response Immune Response Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Axon Guidance Blood Circulation Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Response To Mechanical Stimulus Response To Virus T Cell Chemotaxis Telencephalon Cell Migration Positive Regulation Of Cell Migration Animal Organ Regeneration Killing Of Cells Of Another Organism Positive Regulation Of Dopamine Secretion Integrin Activation Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway CXCL12-activated CXCR4 Signaling Pathway Response To Peptide Hormone Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Chemotaxis Induction Of Positive Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Vasculature Development Response To Ultrasound Cellular Response To Chemokine Positive Regulation Of T Cell Migration Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways			Nuclear signaling by ERBB4 Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Estrogen-dependent gene expression
Drugs			CTCE-0214 Tinzaparin
Diseases
GWAS			Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Blood protein levels ( 30072576) Body mass index ( 25760438) Coronary artery disease ( 32469254 24262325 26708285 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449 21378990) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Myeloid white cell count ( 27863252) Myocardial infarction ( 26343387 33532862) Myocardial infarction (early onset) ( 19198609) Neutrophil count ( 27863252 32888494) QT interval (ambient particulate matter interaction) ( 28749367) Red blood cell count ( 32888494) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Schizophrenia ( 23212062) Smoking initiation (ever regular vs never regular) ( 31089300) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		168 interacting genes: AATF ACOT7 AOC1 ARID5A ATXN1 ATXN1L BAG3 BATF2 BHLHE40 C1orf94 CALCOCO2 CAMK2A CAPN15 CCDC120 CDK4 CELF5 CEP70 CLASRP COL4A2 COL4A5 CXCL12 DAB1 DAZ1 DAZL DCUN1D1 DESI1 DTX2 EPN1 EPN2 EPN3 ESRP1 EXD3 FAM168A FAM83A FBN3 FOXH1 GGA3 GPS2 GPSM1 HEY1 HGS HIP1 HIPK2 INCA1 KLHL42 KRTAP19-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 LGALS9 LITAF LMO2 MAGED1 MAPK1IP1L MED31 MINDY1 MINDY3 MTURN MYEOV MYOZ3 NDUFA5 NEDD4 NEDD4L NOC4L NOTCH1 OPTN OTUB2 OTUD7B OTULIN PATZ1 PDIK1L PEF1 PITX2 PLEKHB2 PLEKHF2 PLSCR1 PLSCR4 POGZ POLI PROP1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PRR34 RABGEF1 RAD18 RAD23A RAMAC RBFOX1 RBFOX2 RBM11 RBM24 RBM43 RBPMS RHOXF2 RNF115 RNF208 RNF44 ROR2 RPS27A RUNX1 SEPTIN2 SIAH1 SMAP2 SMURF2 SNRPC SOX10 SOX6 SPMIP9 SQSTM1 STAM2 STAT6 TAX1BP1 TBX6 TCF7L2 TENT5B TENT5C TFG TIAL1 TLE1 TLE5 TNIP1 TNIP3 TOLLIP TOM1 TP53 UBA52 UBAC1 UBAP2 UBASH3A UBASH3B UBB UBC UBE2D4 UBE2E2 UBE2E3 UBE2V1 UBE3A UBQLN1 UBQLN2 UBQLN4 UBXN6 UBXN7 USP13 USP5 VENTX VEZF1 VHLL VPS37C WDR73 WWOX WWP1 YOD1 ZBTB32 ZC3H10 ZFAND2A ZFAND2B ZFYVE9 ZNF34 ZNF581	30 interacting genes: CCL11 CCL13 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CD4 CTSG CXCL10 CXCL11 CXCL14 CXCL17 CXCL2 CXCL6 CXCL9 CXCR4 DAZAP2 DPP4 ELANE FBXO7 FN1 MMP2 PF4 PF4V1 PPBP VCAN XCL1 XCL2
Entrez ID		9802	6387
HPRD ID		08463	02904
Ensembl ID		ENSG00000183283	ENSG00000107562
Uniprot IDs		Q15038	P48061
PDB IDs			1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2N55 2NWG 2SDF 3GV3 3HP3 4LMQ 4UAI 6SHR 7SK3 7SK4 7SK5 7SK6 7SK7 7SK8 8K3Z 8U4O
Enriched GO Terms of Interacting Partners?		Protein Binding Polyubiquitin Modification-dependent Protein Binding Post-translational Protein Modification Ubiquitin Binding Nucleus Protein Ubiquitination Protein Modification By Small Protein Conjugation Nucleoplasm Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Protein Catabolic Process Autophagy Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process K48-linked Deubiquitinase Activity Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Cysteine-type Deubiquitinase Activity Positive Regulation Of Metabolic Process Macroautophagy Protein K48-linked Deubiquitination Negative Regulation Of Signal Transduction Cysteine-type Peptidase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Protein Tag Activity Protein Metabolic Process Identical Protein Binding Cytosol Autophagosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Removal Clathrin Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Macroautophagy Establishment Of Protein Localization To Vacuole	Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Leukocyte Chemotaxis Leukocyte Migration Cell Migration Humoral Immune Response Cytokine Activity Myeloid Leukocyte Migration Cell Motility Killing Of Cells Of Another Organism Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Cell Killing Chemokine-mediated Signaling Pathway Defense Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Extracellular Space Response To Other Organism Immune Response Response To External Biotic Stimulus Mononuclear Cell Migration Extracellular Region Cytokine-mediated Signaling Pathway CXCR Chemokine Receptor Binding CCR Chemokine Receptor Binding Response To Stress Regulation Of Locomotion Neutrophil Chemotaxis Regulation Of Cell Migration Neutrophil Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Binding Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway CXCR3 Chemokine Receptor Binding Response To Molecule Of Bacterial Origin Signal Transduction Cellular Response To Lipid
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