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NTRK1 and NGF
Number of citations of the paper that reports this interaction (PubMedID
10490030
)
0
Data Source:
BioGRID
(x-ray crystallography, x-ray crystallography)
HPRD
(in vivo, in vitro)
NTRK1
NGF
Description
neurotrophic receptor tyrosine kinase 1
nerve growth factor
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Late Endosome
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome
Recycling Endosome Membrane
Extracellular Region
Extracellular Space
Endosome
Golgi Lumen
Cytosol
Synaptic Vesicle
Axon
Dendrite
Endosome Lumen
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Activity
Transferase Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Enzyme Inhibitor Activity
Signaling Receptor Binding
Nerve Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Metalloendopeptidase Inhibitor Activity
Lipid Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Peptidase Inhibitor Activity
Death Receptor Agonist Activity
Biological Process
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Nervous System Development
Axon Guidance
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
Cell Differentiation
B Cell Differentiation
Neuron Projection Development
Response To Nutrient Levels
Response To Nicotine
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Sympathetic Nervous System Development
Neuron Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neuron Apoptotic Process
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Innervation
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Growth Factor Stimulus
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Peripheral Nervous System Development
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Maturation
Sensory Perception Of Pain
Nerve Development
Neuron Projection Development
Positive Regulation Of Protein Ubiquitination
Nerve Growth Factor Signaling Pathway
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Axon Extension
Positive Regulation Of Ras Protein Signal Transduction
Regulation Of Neurotransmitter Secretion
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Collateral Sprouting
Axon Extension
Neuron Projection Morphogenesis
Modulation Of Chemical Synaptic Transmission
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
PLC-gamma1 signalling
Signalling to RAS
NGF processing
NGF processing
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Clenbuterol
RI 624
Polaprezinc
Fasinumab
Oleandrin
Diseases
Neuroblastoma
Thyroid cancer
GWAS
Red cell distribution width (
32888494
)
Coronary artery disease (
33020668
)
Diastolic blood pressure (
27841878
)
Dysmenorrheic pain (
27454463
)
Dysmenorrheic pain severity (
29855537
)
Menstruation quality of life impact (dysmenorrhea) (
29855537
)
Migraine (
27182965
27322543
)
Migraine without aura (
27322543
)
Obstetric antiphospholipid syndrome (
28424481
)
Pain medicine use during menstruation (
29855537
)
Pediatric non-alcoholic fatty liver disease activity score (
23535911
)
Red blood cell count (
32888494
)
Schizophrenia (
30285260
)
Systolic blood pressure (
27841878
)
Interacting Genes
41 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
HIPK2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
11 interacting genes:
A2M
CRYAB
ITGA9
ITGB1
LRP1
MMP7
NGFR
NTRK1
PLG
SORCS3
SORT1
Entrez ID
4914
4803
HPRD ID
01869
08874
Ensembl ID
ENSG00000198400
ENSG00000134259
Uniprot IDs
P04629
X5DR71
A0A346FYQ1
P01138
PDB IDs
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
7N3T
7VKM
7VKN
7VKO
7XAF
7XBI
8J5W
8J5X
8J61
8J63
8YTD
8YTE
1SG1
1WWW
2IFG
4EDW
4EDX
4ZBN
5JZ7
6YW8
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Phosphotyrosine Residue Binding
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytosol
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
ERBB Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Neurotrophin TRKA Receptor Binding
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Insulin Receptor Binding
Neurotrophin Signaling Pathway
Plasma Membrane
Regulation Of Apoptotic Process
Nerve Growth Factor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Regulation Of Programmed Cell Death
Intracellular Signaling Cassette
Signaling Adaptor Activity
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Population Proliferation
Ephrin Receptor Binding
Protein Kinase Binding
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune Response
Positive Regulation Of D-glucose Import
Regulation Of Cell Adhesion
Enzyme Binding
Regulation Of Cellular Localization
SH2 Domain Binding
Insulin-like Growth Factor Receptor Binding
Developmental Process
Positive Regulation Of D-glucose Transmembrane Transport
Regulation Of Biological Quality
Negative Regulation Of Programmed Cell Death
Nerve Growth Factor Binding
Cell Surface
Integrin Alpha9-beta1 Complex
Nerve Growth Factor Receptor Activity
Neurotrophin Binding
Integrin Binding Involved In Cell-matrix Adhesion
Cellular Response To Amyloid-beta
Synaptic Membrane
Cerebellar Climbing Fiber To Purkinje Cell Synapse
Modulation Of Chemical Synaptic Transmission
Response To Amyloid-beta
Signaling Receptor Activity
Amyloid-beta Binding
Negative Regulation Of Vasoconstriction
Enzyme-linked Receptor Protein Signaling Pathway
Nerve Growth Factor Signaling Pathway
Protease Binding
Neurotrophin TRK Receptor Signaling Pathway
Apolipoprotein Binding
Detection Of Temperature Stimulus
Dendritic Spine
Response To Temperature Stimulus
System Process
Integrin Complex
Neurotrophin Signaling Pathway
Plasma Membrane
Myoblast Differentiation
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Cell Migration
Receptor Complex
Regulation Of Cell Motility
Regulation Of Locomotion
Extracellular Matrix Disassembly
Nerve Development
Extracellular Matrix Organization
Extracellular Structure Organization
Vascular Process In Circulatory System
Myoblast Fate Specification
Learning Or Memory
Coreceptor Activity
Integrin Alpha7-beta1 Complex
Positive Regulation Of Transcytosis
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Antibacterial Peptide Secretion
Neurotrophin P75 Receptor Binding
Neurotensin Receptor Activity, Non-G Protein-coupled
Cell Surface Receptor Signaling Pathway
Endosome Membrane
Platelet Alpha Granule Lumen
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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