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NTRK1 and FRS2
Number of citations of the paper that reports this interaction (PubMedID
10092678
)
0
Data Source:
HPRD
(in vitro)
NTRK1
FRS2
Description
neurotrophic receptor tyrosine kinase 1
fibroblast growth factor receptor substrate 2
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Late Endosome
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome
Recycling Endosome Membrane
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Endomembrane System
Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Activity
Transferase Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Fibroblast Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phosphatase Activator Activity
Biological Process
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Nervous System Development
Axon Guidance
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
Cell Differentiation
B Cell Differentiation
Neuron Projection Development
Response To Nutrient Levels
Response To Nicotine
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Sympathetic Nervous System Development
Neuron Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neuron Apoptotic Process
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Innervation
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Growth Factor Stimulus
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Gastrulation With Mouth Forming Second
Organ Induction
Lens Development In Camera-type Eye
Ventricular Septum Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Neuroblast Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Anterior/posterior Axis Specification, Embryo
Forebrain Development
Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Lens Placode Formation Involved In Camera-type Eye Formation
Regulation Of Epithelial Cell Proliferation
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Lens Fiber Cell Development
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
PI3K Cascade
PIP3 activates AKT signaling
Frs2-mediated activation
Frs2-mediated activation
Signaling by ALK
Constitutive Signaling by Aberrant PI3K in Cancer
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by ALK fusions and activated point mutants
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Diseases
Neuroblastoma
Thyroid cancer
GWAS
Red cell distribution width (
32888494
)
Complete remission in asthma (
29786918
)
Heel bone mineral density (
30598549
)
Height (
18391951
20881960
23563607
25282103
25429064
31562340
)
Hip circumference adjusted for BMI (
25673412
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Microalbuminuria (
31511532
)
Response to antidepressants (symptom remission) (
29160301
)
Response to diuretic therapy (
18591461
)
Thyroid stimulating hormone levels (
32769997
)
Urinary albumin-to-creatinine ratio (
31511532
)
Interacting Genes
41 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
HIPK2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
28 interacting genes:
BECN1
CBL
CDK3
CRK
DDR1
FGFR1
GAB1
GRB2
INSR
KDR
MAPK1
MAPK3
NCK1
NTRK1
NTRK2
NTRK3
PAK1
PIN1
PRKCI
PRKCZ
PTPN11
PTPRF
RET
RND1
RPS6
SOS1
SRC
YJU2
Entrez ID
4914
10818
HPRD ID
01869
06372
Ensembl ID
ENSG00000198400
ENSG00000166225
Uniprot IDs
P04629
X5DR71
L7RTG7
Q8WU20
PDB IDs
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
7N3T
7VKM
7VKN
7VKO
7XAF
7XBI
8J5W
8J5X
8J61
8J63
8YTD
8YTE
1XR0
2MFQ
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Phosphotyrosine Residue Binding
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytosol
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
ERBB Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Neurotrophin TRKA Receptor Binding
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Insulin Receptor Binding
Neurotrophin Signaling Pathway
Plasma Membrane
Regulation Of Apoptotic Process
Nerve Growth Factor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Regulation Of Programmed Cell Death
Intracellular Signaling Cassette
Signaling Adaptor Activity
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Population Proliferation
Ephrin Receptor Binding
Protein Kinase Binding
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune Response
Positive Regulation Of D-glucose Import
Regulation Of Cell Adhesion
Enzyme Binding
Regulation Of Cellular Localization
SH2 Domain Binding
Insulin-like Growth Factor Receptor Binding
Developmental Process
Positive Regulation Of D-glucose Transmembrane Transport
Regulation Of Biological Quality
Negative Regulation Of Programmed Cell Death
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Response To Growth Factor
Signal Transduction
Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Cellular Component Organization
Positive Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Protein Tyrosine Kinase Activity
Cell Migration
Ephrin Receptor Signaling Pathway
Protein Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Cell Motility
Protein Autophosphorylation
ERBB Signaling Pathway
Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Projection Development
Phosphotyrosine Residue Binding
Positive Regulation Of Cell Projection Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Projection Organization
Cell Development
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Migration
ATP Binding
Receptor Complex
Ephrin Receptor Binding
Positive Regulation Of Cell Motility
Neurotrophin Signaling Pathway
Nucleotide Binding
Transferase Activity
Positive Regulation Of Locomotion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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