NTRK1 and SORT1

Number of citations of the paper that reports this interaction (PubMedID 21102451)
56

Data Source:
BioGRID (pull down)

		NTRK1	SORT1
Description		neurotrophic receptor tyrosine kinase 1	sortilin 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endosome Early Endosome Late Endosome Plasma Membrane Cell Surface Endosome Membrane Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Neuronal Cell Body Receptor Complex Recycling Endosome Recycling Endosome Membrane	Nucleus Lysosome Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Protein Homodimerization Activity Neurotrophin Binding Nerve Growth Factor Binding	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding
	Biological Process	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Axon Guidance Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Programmed Cell Death Involved In Cell Development Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development Cell Differentiation B Cell Differentiation Neuron Projection Development Response To Nutrient Levels Response To Nicotine Peptidyl-tyrosine Autophosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Neuron Apoptotic Process Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Innervation Axonogenesis Involved In Innervation Behavioral Response To Formalin Induced Pain Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Growth Factor Stimulus Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus	Ossification Protein Targeting To Lysosome Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Cell Differentiation Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation D-glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Golgi To Lysosome Transport Maintenance Of Synapse Structure
Pathways		PLC-gamma1 signalling Signalling to RAS ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling NGF-independant TRKA activation TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN PI3K/AKT activation PI3K/AKT activation Signalling to STAT3	Golgi Associated Vesicle Biogenesis
Drugs		Amitriptyline Imatinib Regorafenib Entrectinib Fostamatinib Cenegermin Larotrectinib Pralsetinib
Diseases		Neuroblastoma Thyroid cancer
GWAS		Red cell distribution width ( 32888494)	Abdominal aortic aneurysm ( 27899403) Appendicular lean mass ( 33097823) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 18193044 25961943 18193043 19060906 19060910 24097068 20686565 21347282) LDL cholesterol levels ( 26690388 28334899) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733) Metabolite levels ( 21909109) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Total cholesterol levels ( 28334899)
Interacting Genes		41 interacting genes: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 ERBB2 FRS2 FRS3 GIPC1 GRB2 HIPK2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 PTPRR RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TPTE TRAF4 TRAF6 UBB	17 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTF3 NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF
Entrez ID		4914	6272
HPRD ID		01869	03910
Ensembl ID		ENSG00000198400	ENSG00000134243
Uniprot IDs		P04629 X5DR71	Q99523
PDB IDs		1HE7 1SHC 1WWA 1WWW 2IFG 2N90 4AOJ 4CRP 4F0I 4GT5 4PMM 4PMP 4PMS 4PMT 4YNE 4YPS 5H3Q 5I8A 5JFS 5JFV 5JFW 5JFX 5KMI 5KMJ 5KMK 5KML 5KMM 5KMN 5KMO 5KVT 5WR7 6D1Y 6D1Z 6D20 6D22 6DKB 6DKG 6DKI 6DKW 6IQN 6J5L 6NPT 6NSP 6NSS 6PL1 6PL2 6PL3 6PL4 6PMA 6PMB 6PMC 6PME 7N3T 7VKM 7VKN 7VKO 7XAF 7XBI 8J5W 8J5X 8J61 8J63 8YTD 8YTE	3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphotyrosine Residue Binding Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Neurotrophin TRKA Receptor Binding Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Insulin Receptor Binding Neurotrophin Signaling Pathway Plasma Membrane Regulation Of Apoptotic Process Nerve Growth Factor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of Programmed Cell Death Intracellular Signaling Cassette Signaling Adaptor Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Ephrin Receptor Binding Protein Kinase Binding Positive Regulation Of Cell Population Proliferation Regulation Of Immune Response Positive Regulation Of D-glucose Import Regulation Of Cell Adhesion Enzyme Binding Regulation Of Cellular Localization SH2 Domain Binding Insulin-like Growth Factor Receptor Binding Developmental Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Biological Quality Negative Regulation Of Programmed Cell Death	Neurotrophin Signaling Pathway Neurotrophin Binding Nerve Development Nerve Growth Factor Signaling Pathway Neurotrophin Receptor Activity Nerve Growth Factor Receptor Binding Endosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Endosome Membrane Positive Regulation Of Neuron Projection Development Positive Regulation Of Synapse Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Axonogenesis Early Endosome Membrane Enzyme-linked Receptor Protein Signaling Pathway Axon Mechanoreceptor Differentiation Regulation Of Nervous System Development Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cell Junction Assembly Dendrite Regulation Of Neuron Apoptotic Process Rhythmic Process Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Nervous System Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Nerve Growth Factor Binding Cellular Response To Nerve Growth Factor Stimulus Regulation Of Axonogenesis Signal Transduction Nervous System Development Early Endosome Response To Nerve Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synapse Assembly Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Regulation Of Signal Transduction Establishment Of Protein Localization To Plasma Membrane System Development Signaling Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?