NTRK1 and MATK

Number of citations of the paper that reports this interaction (PMID 10329710)
4

Data Source:
BioGRID (far western blotting)
HPRD (in vivo)

		NTRK1	MATK
Gene Name		neurotrophic tyrosine kinase, receptor, type 1	megakaryocyte-associated tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus	Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Cell Proliferation Positive Regulation Of Cell Proliferation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response
Pathways		Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation	Signaling by ERBB2
Drugs		Amitriptyline Imatinib Regorafenib
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB	10 interactors: CACNA1A CD36 ERBB2 EWSR1 KIT LYN NTRK1 PTK2B PXN SRC
Entrez ID		4914	4145
HPRD ID		01869	02496
Ensembl ID		ENSG00000198400	ENSG00000007264
Uniprot IDs		P04629	F1T0G6 K7EQY5 P42679
PDB IDs		1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5	1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity	Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Regulation Of Kinase Activity Regulation Of Lipid Kinase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Cell Projection Organization Peptidyl-amino Acid Modification Signal Complex Assembly Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Development Response To External Stimulus Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Activation Cell Surface Receptor Signaling Pathway Leukocyte Differentiation Cell Morphogenesis Involved In Differentiation Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Response To Stress
Tagcloud ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc	atpb barcodes barcoding biodiversity characters chloroplast classifying cox1 discipline endangered epitome fashionable forensic fundamentally gapdh helping identifications molecularization naming ndhf orthologous rbcl revolutionary stretches suddenly taxonomist taxonomy transitioning trnl
Tagcloud (Difference) ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc	atpb barcodes barcoding biodiversity characters chloroplast classifying cox1 discipline endangered epitome fashionable forensic fundamentally gapdh helping identifications molecularization naming ndhf orthologous rbcl revolutionary stretches suddenly taxonomist taxonomy transitioning trnl
Tagcloud (Intersection) ?