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NTRK1 and DNAJA3
Number of citations of the paper that reports this interaction (PubMedID
35384245
)
105
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid, in vitro, in vivo)
NTRK1
DNAJA3
Description
neurotrophic receptor tyrosine kinase 1
DnaJ heat shock protein family (Hsp40) member A3
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Late Endosome
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome
Recycling Endosome Membrane
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Actin Filament
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Membrane
Neuromuscular Junction
Mitochondrial Nucleoid
Synapse
Postsynaptic Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Activity
Transferase Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Signaling Receptor Binding
Type II Interferon Receptor Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Protein Kinase Binding
Hsp70 Protein Binding
GTPase Regulator Activity
Heat Shock Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
NF-kappaB Binding
Unfolded Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
IkappaB Kinase Complex Binding
DNA-binding Transcription Factor Binding
Biological Process
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Nervous System Development
Axon Guidance
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
Cell Differentiation
B Cell Differentiation
Neuron Projection Development
Response To Nutrient Levels
Response To Nicotine
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Sympathetic Nervous System Development
Neuron Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neuron Apoptotic Process
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Innervation
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Growth Factor Stimulus
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Immune System Process
Mitochondrial DNA Replication
Protein Folding
Apoptotic Process
Activation-induced Cell Death Of T Cells
Response To Stress
Mitochondrion Organization
Small GTPase-mediated Signal Transduction
Neuromuscular Junction Development
Negative Regulation Of Cell Population Proliferation
Response To Heat
Positive Regulation Of Protein Ubiquitination
T Cell Differentiation In Thymus
Response To Type II Interferon
Positive Regulation Of T Cell Proliferation
Regulation Of Cell Population Proliferation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Protein Stabilization
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Skeletal Muscle Acetylcholine-gated Channel Clustering
Cellular Senescence
Pathways
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Diseases
Neuroblastoma
Thyroid cancer
GWAS
Red cell distribution width (
32888494
)
Erectile dysfunction (
30583798
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Immature fraction of reticulocytes (
32888494
)
Schizophrenia (
28991256
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
41 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
HIPK2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
47 interacting genes:
ATOSB
ATXN1
BRCA1
CACNA1C
CARM1
CATSPERT
CIDEB
COIL
CYSRT1
FAM131C
FBXO7
FOSL2
FRMD6
FXR1
GCC1
GFI1B
GRB2
HSPA1A
HSPA8
IFNGR2
INPP5J
JAK2
KDM1A
KRAS
LAMTOR5
MCPH1
MET
MYO15B
NFKBIA
NFKBIB
NOC4L
NTRK1
OSGIN1
PRMT6
PTEN
RAD51
RASA1
RELA
RNF34
SHANK3
SMAD9
SMARCB1
STK16
TCF19
USP7
VHL
ZBTB22
Entrez ID
4914
9093
HPRD ID
01869
09758
Ensembl ID
ENSG00000198400
ENSG00000103423
Uniprot IDs
P04629
X5DR71
B3KM81
Q53G26
Q59E88
Q96EY1
PDB IDs
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
7N3T
7VKM
7VKN
7VKO
7XAF
7XBI
8J5W
8J5X
8J61
8J63
8YTD
8YTE
2CTT
2DN9
6IWS
7X89
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Phosphotyrosine Residue Binding
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytosol
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
ERBB Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Neurotrophin TRKA Receptor Binding
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Insulin Receptor Binding
Neurotrophin Signaling Pathway
Plasma Membrane
Regulation Of Apoptotic Process
Nerve Growth Factor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Regulation Of Programmed Cell Death
Intracellular Signaling Cassette
Signaling Adaptor Activity
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Population Proliferation
Ephrin Receptor Binding
Protein Kinase Binding
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune Response
Positive Regulation Of D-glucose Import
Regulation Of Cell Adhesion
Enzyme Binding
Regulation Of Cellular Localization
SH2 Domain Binding
Insulin-like Growth Factor Receptor Binding
Developmental Process
Positive Regulation Of D-glucose Transmembrane Transport
Regulation Of Biological Quality
Negative Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Enzyme Binding
Regulation Of Cell Development
Regulation Of Cell Differentiation
Nucleoplasm
Regulation Of RNA Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Nucleobase-containing Compound Metabolic Process
P53 Binding
Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Identical Protein Binding
Regulation Of Developmental Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Intracellular Signal Transduction
Protein-containing Complex
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Programmed Cell Death
Histone H3R2 Methyltransferase Activity
Positive Regulation Of Nervous System Development
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Apoptotic Process
Regulation Of Gene Expression
Positive Regulation Of Cell Differentiation
Histone Arginine N-methyltransferase Activity
Regulation Of Nervous System Development
Positive Regulation Of Transcription By RNA Polymerase II
Response To Steroid Hormone
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Neurogenesis
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Primary Metabolic Process
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Tagcloud (Intersection)
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