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CD19 and BTK
Number of citations of the paper that reports this interaction (PubMedID
10201980
)
0
Data Source:
HPRD
(in vitro)
CD19
BTK
Description
CD19 molecule
Bruton tyrosine kinase
Image
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Protein-containing Complex
Membrane Raft
Extracellular Exosome
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Zinc Ion Binding
Lipid Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Identical Protein Binding
Phospholipase Binding
Metal Ion Binding
Biological Process
B-1 B Cell Differentiation
Adaptive Immune Response
B Cell Proliferation Involved In Immune Response
Immune System Process
Immunoglobulin Mediated Immune Response
B Cell Mediated Immunity
B Cell Proliferation
Antigen Receptor-mediated Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Regulation Of B Cell Activation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Neutrophil Homeostasis
Positive Regulation Of Type III Hypersensitivity
Positive Regulation Of Type I Hypersensitivity
Negative Regulation Of Cytokine Production
Adaptive Immune Response
B Cell Affinity Maturation
Immune System Process
Histamine Secretion By Mast Cell
Positive Regulation Of Immunoglobulin Production
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Apoptotic Process
Mesoderm Development
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
Proteoglycan Catabolic Process
Negative Regulation Of B Cell Proliferation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
B Cell Activation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Cell Maturation
Positive Regulation Of Phagocytosis
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of B Cell Activation
Negative Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Monocyte Proliferation
Negative Regulation Of Leukocyte Proliferation
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Cellular Response To Interleukin-7
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Positive Regulation Of Interleukin-17A Production
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Synoviocyte Proliferation
Eosinophil Homeostasis
Pathways
PIP3 activates AKT signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Constitutive Signaling by Aberrant PI3K in Cancer
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
G alpha (q) signalling events
G alpha (12/13) signalling events
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate WASPs and WAVEs
G beta:gamma signalling through BTK
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Coltuximab ravtansine
Blinatumomab
Depatuxizumab mafodotin
Inebilizumab
Tisagenlecleucel
Axicabtagene ciloleucel
Tafasitamab
Brexucabtagene autoleucel
Loncastuximab tesirine
Lisocabtagene maraleucel
Dasatinib
Inositol 1,3,4,5-Tetrakisphosphate
XL418
Ibrutinib
Acalabrutinib
Spebrutinib
Fostamatinib
Fenebrutinib
Zanubrutinib
Evobrutinib
Tirabrutinib
Abivertinib
Branebrutinib
Vecabrutinib
Diseases
Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Body mass index (
29273807
)
Brain morphology (MOSTest) (
32665545
)
Crohn's disease (
21102463
28067908
)
Inflammatory bowel disease (
28067908
)
Intelligence (MTAG) (
29326435
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
21 interacting genes:
ABL1
BTK
CBL
CD22
CD79A
CD79B
CD81
CD82
CD9
CR2
ECT2
FYN
GRB2
LYN
MAPK1
PIK3R1
PLCG2
SOS1
SYK
VAV1
VAV2
77 interacting genes:
ABL1
APP
AR
ARHGAP17
ARID3A
ARRB1
AURKA
BCL2L11
BECN1
BLNK
BMX
CAV1
CBL
CD19
CMTM3
COASY
CPVL
DAPP1
ERBB3
EWSR1
FAS
FASLG
FYN
GAB1
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MDM2
MEOX2
MET
MRPS22
MYD88
PIK3AP1
PIK3R3
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
SMURF1
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
Entrez ID
930
695
HPRD ID
00113
02248
Ensembl ID
ENSG00000177455
ENSG00000010671
Uniprot IDs
P15391
Q06187
Q5JY90
PDB IDs
6AL5
7JIC
7URV
7URX
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
4NWM
4OT5
4OT6
4OTF
4OTQ
4OTR
4RFY
4RFZ
4RG0
4RX5
4YHF
4Z3V
4ZLY
4ZLZ
5BPY
5BQ0
5FBN
5FBO
5J87
5JRS
5KUP
5P9F
5P9G
5P9H
5P9I
5P9J
5P9K
5P9L
5P9M
5T18
5U9D
5VFI
5VGO
5XYZ
5ZZ4
6AUA
6AUB
6BIK
6BKE
6BKH
6BKW
6BLN
6DI0
6DI1
6DI3
6DI5
6DI9
6E4F
6EP9
6HRP
6HRT
6HTF
6J6M
6N9P
6NFH
6NFI
6NZM
6O8I
6OMU
6S90
6TFP
6TSE
6TT2
6TUH
6TVN
6VXQ
6W06
6W07
6W7O
6W8I
6X3N
6X3O
6X3P
6XE4
6YYF
6YYG
6YYK
7KXL
7KXM
7KXN
7KXO
7KXP
7KXQ
7L5O
7L5P
7LTY
7LTZ
7N4Q
7N4R
7N4S
7N5O
7N5R
7N5X
7N5Y
7R60
7R61
7YC9
8DSO
8E2M
8EJB
8FLG
8FLH
8FLL
8FLN
8FLV
8GC7
8GC8
8TU3
8TU4
8TU5
8U2D
8U2E
8YVV
Enriched GO Terms of Interacting Partners
?
Immune Response-activating Cell Surface Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Lymphocyte Activation
Immune Response-activating Signaling Pathway
Positive Regulation Of Immune Response
B Cell Activation
Phosphotyrosine Residue Binding
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Leukocyte Activation
Fc Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Immune Effector Process
Immune System Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway
Regulation Of Cell Activation
Leukocyte Proliferation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Lymphocyte Activation
B Cell Proliferation
Plasma Membrane
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
B Cell Differentiation
Lymphocyte Proliferation
Mononuclear Cell Differentiation
Mononuclear Cell Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Lymphocyte Activation
Ephrin Receptor Binding
Immune Response
Leukocyte Differentiation
Lymphocyte Differentiation
Positive Regulation Of Signal Transduction
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of T Cell Activation
Cellular Developmental Process
Positive Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Defense Response
Immune Response-regulating Signaling Pathway
Signal Transduction
Immune Response-activating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Immune Response
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Immune Response
Kinase Activity
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Positive Regulation Of Intracellular Signal Transduction
Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Innate Immune Response-activating Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
B Cell Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Intracellular Signaling Cassette
Leukocyte Activation
Cytoplasm
Antigen Receptor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Cell Activation
Regulation Of Programmed Cell Death
Positive Regulation Of Defense Response
Positive Regulation Of Metabolic Process
Toll-like Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Cell Surface Pattern Recognition Receptor Signaling Pathway
Response To Lipid
Positive Regulation Of Canonical NF-kappaB Signal Transduction
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Tagcloud (Intersection)
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