CD19 and CD22

Number of citations of the paper that reports this interaction (PubMedID 9120258)
0

Data Source:
HPRD (in vivo)

		CD19	CD22
Description		CD19 molecule	CD22 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Protein-containing Complex Membrane Raft Extracellular Exosome	Cytoplasm Early Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome
	Molecular Function		IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding
	Biological Process	B-1 B Cell Differentiation Adaptive Immune Response B Cell Proliferation Involved In Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity B Cell Proliferation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Negative Regulation Of Immunoglobulin Production Negative Regulation Of Immune System Process Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Coltuximab ravtansine Blinatumomab Depatuxizumab mafodotin Inebilizumab Tisagenlecleucel Axicabtagene ciloleucel Tafasitamab Brexucabtagene autoleucel Loncastuximab tesirine Lisocabtagene maraleucel	Epratuzumab Inotuzumab ozogamicin Moxetumomab pasudotox
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Waist circumference adjusted for body mass index ( 34021172)	Red cell distribution width ( 32888494)
Interacting Genes		21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2	21 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 CFTR GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140
Entrez ID		930	933
HPRD ID		00113	00114
Ensembl ID		ENSG00000177455	ENSG00000012124
Uniprot IDs		P15391	P20273 Q0EAF5
PDB IDs		6AL5 7JIC 7URV 7URX	5VKJ 5VKM 5VL3 7O52
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Lymphocyte Activation Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response B Cell Activation Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Effector Process Immune System Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Regulation Of Cell Activation Leukocyte Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Activation B Cell Proliferation Plasma Membrane Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Lymphocyte Proliferation Mononuclear Cell Differentiation Mononuclear Cell Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Immune Response Leukocyte Differentiation Lymphocyte Differentiation Positive Regulation Of Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Cellular Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Defense Response	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Neurotrophin TRKA Receptor Binding Positive Regulation Of Immune Response Phosphotyrosine Residue Binding Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of B Cell Activation Negative Regulation Of Defense Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Multicellular Organismal Development Leukocyte Activation T Cell Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Response To Other Organism Immune Effector Process Lymphocyte Mediated Immunity Immune System Process Regulation Of Sequestering Of Calcium Ion Cell Activation Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transport Response To External Biotic Stimulus Defense Response Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Mediated Cytotoxicity Negative Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol B Cell Activation Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Defense Response Membrane Raft Immune Response Ephrin Receptor Binding Positive Regulation Of Cell Activation
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