CD19 and CD79B

Number of citations of the paper that reports this interaction (PubMedID 9120258)
0

Data Source:
HPRD (in vivo)

		CD19	CD79B
Description		CD19 molecule	CD79b molecule
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Protein-containing Complex Membrane Raft Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Membrane B Cell Receptor Complex Extracellular Exosome IgM B Cell Receptor Complex
	Molecular Function		Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	B-1 B Cell Differentiation Adaptive Immune Response B Cell Proliferation Involved In Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity B Cell Proliferation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Adaptive Immune Response Immune System Process Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium B Cell Differentiation B Cell Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	CD22 mediated BCR regulation Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Coltuximab ravtansine Blinatumomab Depatuxizumab mafodotin Inebilizumab Tisagenlecleucel Axicabtagene ciloleucel Tafasitamab Brexucabtagene autoleucel Loncastuximab tesirine Lisocabtagene maraleucel	Polatuzumab vedotin
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Waist circumference adjusted for body mass index ( 34021172)	Height ( 25282103) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2	14 interacting genes: BLK CD19 CD3E CD5 CD79A FYN LCK LYN PTK2 PTPN6 SGTA SGTB SYK ZAP70
Entrez ID		930	974
HPRD ID		00113	00922
Ensembl ID		ENSG00000177455	ENSG00000007312
Uniprot IDs		P15391	P40259
PDB IDs		6AL5 7JIC 7URV 7URX	3KG5 7WSO 7WSP 7XQ8 7XT6
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Lymphocyte Activation Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response B Cell Activation Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Effector Process Immune System Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Regulation Of Cell Activation Leukocyte Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Activation B Cell Proliferation Plasma Membrane Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Lymphocyte Proliferation Mononuclear Cell Differentiation Mononuclear Cell Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Immune Response Leukocyte Differentiation Lymphocyte Differentiation Positive Regulation Of Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Cellular Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Defense Response	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response T Cell Costimulation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Protein Tyrosine Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Protein Phosphorylation Regulation Of Cell Adhesion Leukocyte Activation Regulation Of Cell Adhesion Mediated By Integrin Phosphorylation Lymphocyte Proliferation Positive Regulation Of Cell Activation Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Cell Activation Leukocyte Proliferation Regulation Of Leukocyte Proliferation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Positive Regulation Of Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Membrane Raft T Cell Receptor Signaling Pathway Leukocyte Migration SH2 Domain Binding Regulation Of Mononuclear Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding
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