STAT3 and HSP90AA1

Number of citations of the paper that reports this interaction (PubMedID 34987637)
73

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		STAT3	HSP90AA1
Description		signal transducer and activator of transcription 3	heat shock protein 90 alpha family class A member 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Postsynaptic Density Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Protein-containing Complex Secretory Granule Lumen Sperm Flagellum Melanosome Neuronal Cell Body Lysosomal Lumen Myelin Sheath Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Mitochondrial Sheath Sperm Plasma Membrane Protein Folding Chaperone Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Chromatin DNA Binding CCR5 Chemokine Receptor Binding Nuclear Glucocorticoid Receptor Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding LncRNA Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity RNA Sequestering Activity	Nucleotide Binding UTP Binding CTP Binding RNA Binding MRNA Binding Protein Binding ATP Binding GTP Binding Hydrolase Activity ATP Hydrolysis Activity Sulfonylurea Receptor Binding Protein Phosphatase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Ubiquitin Protein Ligase Binding DATP Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein Folding Chaperone Transmembrane Transporter Binding Tau Protein Binding GTPase Binding Rho GDP-dissociation Inhibitor Binding Unfolded Protein Binding DNA Polymerase Binding Scaffold Protein Binding Disordered Domain Specific Binding ATP-dependent Protein Folding Chaperone Enzyme-substrate Adaptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Response To Hypoxia Eye Photoreceptor Cell Differentiation Regulation Of Cytokine Production Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Defense Response Acute-phase Response Inflammatory Response Immune Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Response To Estradiol Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Hormone Stimulus Leptin-mediated Signaling Pathway Response To Cytokine Somatic Stem Cell Population Maintenance Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Eating Behavior MRNA Transcription By RNA Polymerase II Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Peptide Hormone Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Leptin Stimulus Response To Leptin Response To Ethanol Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Membrane Permeability Astrocyte Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Cycle Radial Glial Cell Differentiation Retinal Rod Cell Differentiation Regulation Of Feeding Behavior Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Cellular Response To Cytokine Stimulus T-helper 17 Type Immune Response T-helper 17 Cell Lineage Commitment Positive Regulation Of Extracellular Matrix Disassembly Inflammatory Response To Wounding Energy Homeostasis Cellular Response To Interleukin-17 Cell Surface Receptor Signaling Pathway Via STAT Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Interleukin-10-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Hypoxia Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Stem Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Neuron Migration	Neuron Migration Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Skeletal Muscle Contraction Protein Folding Mitochondrial Transport Response To Unfolded Protein Telomere Maintenance Via Telomerase Response To Heat Response To Cold Response To Xenobiotic Stimulus Response To Salt Stress Positive Regulation Of Lamellipodium Assembly Cardiac Muscle Cell Apoptotic Process Protein Import Into Mitochondrial Matrix Regulation Of Protein Ubiquitination Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Protein Polymerization Positive Regulation Of Interferon-beta Production Regulation Of Protein Localization Cellular Response To Heat Protein Refolding Response To Cocaine Positive Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Protein Unfolding Response To Estrogen Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Size Nitric Oxide Metabolic Process Response To Antibiotic Protein Stabilization Chaperone-mediated Protein Complex Assembly Positive Regulation Of Cardiac Muscle Contraction Chaperone-mediated Autophagy Cellular Response To Virus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurofibrillary Tangle Assembly Telomerase Holoenzyme Complex Assembly
Pathways		Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Signaling by ALK Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT3 nuclear events downstream of ALK signaling Inactivation of CSF3 (G-CSF) signaling Cytoprotection by HMOX1 Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling PKR-mediated signaling Regulation of PD-L1(CD274) transcription	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DDX58/IFIH1-mediated induction of interferon-alpha/beta vRNP Assembly Regulation of actin dynamics for phagocytic cup formation eNOS activation Regulation of PLK1 Activity at G2/M Transition Scavenging by Class F Receptors Scavenging by Class F Receptors HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase HSF1-dependent transactivation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Sema3A PAK dependent Axon repulsion VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability Uptake and function of diphtheria toxin PIWI-interacting RNA (piRNA) biogenesis Anchoring of the basal body to the plasma membrane Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Downregulation of ERBB2 signaling ESR-mediated signaling Extra-nuclear estrogen signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Constitutive Signaling by Overexpressed ERBB2 Aggrephagy Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Assembly and release of respiratory syncytial virus (RSV) virions Respiratory syncytial virus genome replication
Drugs		ENMD-1198 OPB-111077	Rifabutin Nedocromil 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Geldanamycin 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine Quercetin 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE Tanespimycin SNX-5422 N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol CCT-018159 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE Copper Polaprezinc Alvespimycin
Diseases		Oral cancer Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Apolipoprotein B levels ( 32203549) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 18587394 28067908 23266558 21102463) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 30578418) Inflammatory bowel disease ( 23128233 26278503 27569725 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 20159113 31604244 24076602 22190364 21833088) Myocardial infarction ( 33532862) Psoriasis ( 25903422 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		214 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DSCAM DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN ESR1 FAM117B FBXW7 FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GAS5 GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL23R IL2RA IL2RB IL6R IL6ST IL7R IMPDH2 IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MEG3 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFE2L2 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PML POM121 PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RNF31 RPA2 RPL11 RPRD1B RPS6KA1 RPS6KA3 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TAB3 TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2	196 interacting genes: A1BG A2M AGT AHR AHSA1 AHSA2P AHSG AIP AIPL1 AKT1 AKT2 APAF1 APOA1 APOA4 APOB APOE AR ASGR1 BIRC5 BMAL1 BRMS1 BTG3 C3 C4A C4BPA CACYBP CALM1 CDC37 CDC37L1 CDK5R1 CDKN2A CERS2 CFB CFTR CHEK1 CHORDC1 CHUK CKS1B CKS2 COL12A1 CP CRNKL1 CSNK2A1 CSNK2A2 DAP3 DCD DNAJC7 EGFR EGLN1 EIF2AK1 EIF2AK2 EIF2AK3 EIF2S1 EPRS1 ERBB2 ERN1 ESR1 ESRRB FAM162A FANCC FASN FGA FKBP1A FKBP5 FKBP6 FLCN FLG2 FN1 FNIP1 FYN GC GNA12 GSK3A GSN GUCY1B1 GZMA HECTD3 HIF1A HIF3A HP HPR HPX HRNR HSF1 HSPA8 HSPG2 HTT IKBKB IKBKE IKBKG IP6K2 IRAK1 IRF3 ITGB1BP2 ITIH1 JUN JUP KDR KEAP1 LCK LGALS3BP LINC01554 LOXL2 LRP1 LSM1 MAP3K14 MAP3K3 MAPK1 MMP2 MS4A2 MTRNR2L1 MUC1 MYC MYOD1 NDRG1 NOS1 NOS3 NPAS2 NR2C2 NR3C1 NR3C2 NSL1 PABPN1 PAK1 PDPK1 PIM1 PKM PLG PMF1 PPARA PPARD PPID PPIL2 PPP5C PRKCA PRKCD PRKDC PTGDS PTGES3 PTP4A2 PTPRF RAD51 RAF1 RHOBTB2 RIPK1 RIPPLY3 RPAP3 RPS3 RPS3A RUNX1T1 SERPINA1 SERPINA3 SERPINB5 SERPINC1 SERPING1 SGTA SHKBP1 SIM1 SKP1 SLC2A4 SLC34A1 SMYD2 SMYD3 SRC ST13 STARD13 STAT3 STIP1 STUB1 SUGT1 SUMO2 SVIL TBK1 TERT TF THBS1 TJP1 TLN1 TNFRSF1A TOMM34 TOMM40 TOMM70 TP53 TTK TTR UBASH3A UBE2N UCHL1 UNC45A USP19 USP50 WASL WEE2-AS1 YWHAE YWHAZ ZBTB7A
Entrez ID		6774	3320
HPRD ID		00026	00777
Ensembl ID		ENSG00000168610	ENSG00000080824
Uniprot IDs		A0A7I2V395 A0A7I2V444 A0A7I2V4C8 A0A7I2V4R2 A0A7I2V4R3 A0A7I2V552 A0A7I2YQD2 A0A7I2YQR5 P40763	K9JA46 P07900 Q86SX1
PDB IDs		5AX3 5U5S 6NJS 6NUQ 6QHD 6TLC	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5NYH 5NYI 5OCI 5OD7 5ODX 5T21 5VYY 5XQD 5XQE 5XR5 5XR9 5XRB 5XRD 5XRE 5ZR3 6B99 6B9A 6CEO 6CYG 6CYH 6EI5 6EL5 6ELN 6ELO 6ELP 6EY8 6EY9 6EYA 6EYB 6F1N 6FCJ 6FDP 6GP4 6GP8 6GPF 6GPH 6GPO 6GPP 6GPR 6GPT 6GPW 6GPY 6GQ6 6GQR 6GQS 6GQU 6GR1 6GR3 6GR4 6GR5 6HHR 6KSQ 6LR9 6LSZ 6LT8 6LTI 6LTK 6N8X 6OLX 6TN4 6TN5 6U98 6U99 6U9A 6U9B 7DMC 7KRJ 7KW7 7L7I 7L7J 7LSZ 7LT0 7RXZ 7RY0 7RY1 7S8Y 7S8Z 7S90 7S95 7S98 7S99 7S9F 7S9G 7S9H 7S9I 7UR3 8AGI 8AGJ 8AGL 8B7I 8B7J 8FFV 8FFW 8JR6 8JR7 8JRA 8KI4 8SBT 8W4V 8W8K 8X2R 9AUU
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Protein Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Developmental Process Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Cell Population Proliferation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Phosphorylation Regulation Of Signal Transduction Positive Regulation Of DNA-templated Transcription Response To Lipid Positive Regulation Of RNA Biosynthetic Process Regulation Of Immune System Process Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Response To Cytokine Phosphorylation Kinase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Response To Peptide Cell Surface Receptor Signaling Pathway Via STAT	Hsp90 Protein Binding Blood Microparticle Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intracellular Signal Transduction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Intracellular Signaling Cassette Positive Regulation Of Signaling Cellular Response To Stress Regulation Of Signaling Regulation Of Cell Communication Cytosol Protein Metabolic Process Enzyme Binding Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Signal Transduction Kinase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Stability Programmed Cell Death Cytoplasm Cell Death Negative Regulation Of Programmed Cell Death Heat Shock Protein Binding Cellular Response To Oxygen-containing Compound Extracellular Exosome Positive Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Signal Transduction Response To Hormone Protein-folding Chaperone Binding Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Regulation Of Cellular Response To Stress Response To Oxygen Levels Protein Serine/threonine Kinase Activity
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