STAT3 and FGFR4

Number of citations of the paper that reports this interaction (PubMedID 11350938)
71

Data Source:
HPRD (in vitro, in vivo)

		STAT3	FGFR4
Description		signal transducer and activator of transcription 3	fibroblast growth factor receptor 4
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Postsynaptic Density Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Transport Vesicle Receptor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Chromatin DNA Binding CCR5 Chemokine Receptor Binding Nuclear Glucocorticoid Receptor Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding LncRNA Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity RNA Sequestering Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Response To Hypoxia Eye Photoreceptor Cell Differentiation Regulation Of Cytokine Production Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Defense Response Acute-phase Response Inflammatory Response Immune Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Response To Estradiol Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Hormone Stimulus Leptin-mediated Signaling Pathway Response To Cytokine Somatic Stem Cell Population Maintenance Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Eating Behavior MRNA Transcription By RNA Polymerase II Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Peptide Hormone Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Leptin Stimulus Response To Leptin Response To Ethanol Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Membrane Permeability Astrocyte Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Cycle Radial Glial Cell Differentiation Retinal Rod Cell Differentiation Regulation Of Feeding Behavior Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Cellular Response To Cytokine Stimulus T-helper 17 Type Immune Response T-helper 17 Cell Lineage Commitment Positive Regulation Of Extracellular Matrix Disassembly Inflammatory Response To Wounding Energy Homeostasis Cellular Response To Interleukin-17 Cell Surface Receptor Signaling Pathway Via STAT Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Interleukin-10-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Hypoxia Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Stem Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Neuron Migration	Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Glucose Homeostasis Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Proteolysis Protein Autophosphorylation Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Positive Regulation Of DNA Biosynthetic Process
Pathways		Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Signaling by ALK Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT3 nuclear events downstream of ALK signaling Inactivation of CSF3 (G-CSF) signaling Cytoprotection by HMOX1 Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling PKR-mediated signaling Regulation of PD-L1(CD274) transcription	PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding FGFR4 mutant receptor activation FGFR4 ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling Signaling by FGFR4 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		ENMD-1198 OPB-111077	Heparin Ponatinib Lenvatinib Infigratinib Erdafitinib Pemigatinib Futibatinib
Diseases		Oral cancer Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Apolipoprotein B levels ( 32203549) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 18587394 28067908 23266558 21102463) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 30578418) Inflammatory bowel disease ( 23128233 26278503 27569725 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 20159113 31604244 24076602 22190364 21833088) Myocardial infarction ( 33532862) Psoriasis ( 25903422 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908)	A body shape index ( 34021172) Activated partial thromboplastin time ( 22703881) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340 28552196) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hip shape (DXA scan) ( 30320955) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Type 2 diabetes ( 30718926 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 26785701)
Interacting Genes		214 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DSCAM DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN ESR1 FAM117B FBXW7 FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GAS5 GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL23R IL2RA IL2RB IL6R IL6ST IL7R IMPDH2 IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MEG3 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFE2L2 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PML POM121 PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RNF31 RPA2 RPL11 RPRD1B RPS6KA1 RPS6KA3 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TAB3 TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2	82 interacting genes: ABCB5 AKT1 ANGPTL4 ARAF ARNT BECN1 BLID CASC3 CBLC CCND2 CCNE1 CD44 CDH2 CDK4 CDK6 CDKN2A CDKN2B CDKN2C DIRAS3 EPHA4 EPSTI1 ERBB2 ERRFI1 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FZR1 GLCE GLIS2 GRM1 HGF HIF1A IGF1R KDELR2 LATS2 LRATD2 MAP2K5 MAP2K6 MAP3K5 MAPK14 MDM4 MET MSH2 MTA3 MYC NF2 NSD3 OSGIN1 PDLIM2 PLCG1 PPP3CA PSMC3IP PTPN11 PTPN12 PTPN6 PTPRR RAF1 RASL10B RASSF1 RNF20 ROS1 SCGB3A1 SNCA STAT1 STAT3 STK11 TEAD2 TERT THRSP TP53 TSC1 TTYH2 WIF1
Entrez ID		6774	2264
HPRD ID		00026	00625
Ensembl ID		ENSG00000168610	ENSG00000160867
Uniprot IDs		A0A7I2V395 A0A7I2V444 A0A7I2V4C8 A0A7I2V4R2 A0A7I2V4R3 A0A7I2V552 A0A7I2YQD2 A0A7I2YQR5 P40763	B4DVP5 J3KPQ0 P22455
PDB IDs		5AX3 5U5S 6NJS 6NUQ 6QHD 6TLC	4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG 5NUD 5NWZ 5XFF 5XFJ 6IUO 6IUP 6J6Y 6JPE 6JPJ 6NVG 6NVH 6NVI 6NVJ 6NVK 6V9C 6YI8 7DTZ 7F3M 7N1J 7TYD 7V29 7VJL 7WCT 7WCW 7WCX 7YBO 7YBP 7YBX 7YC1 7YC3 7YSW 8KH6 8KH7 8KH8 8KH9 8W5C 8XLQ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Protein Kinase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Developmental Process Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Cell Population Proliferation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Phosphorylation Regulation Of Signal Transduction Positive Regulation Of DNA-templated Transcription Response To Lipid Positive Regulation Of RNA Biosynthetic Process Regulation Of Immune System Process Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Response To Cytokine Phosphorylation Kinase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Response To Peptide Cell Surface Receptor Signaling Pathway Via STAT	Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Cell Differentiation Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cellular Developmental Process Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Neurogenesis Intracellular Signal Transduction Negative Regulation Of Signaling Regulation Of Cell Motility Negative Regulation Of Cell Communication Growth Factor Activity Negative Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Programmed Cell Death Fibroblast Growth Factor Receptor Binding Intracellular Signaling Cassette Animal Organ Development Regulation Of Apoptotic Process Developmental Process Regulation Of Developmental Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition Protein Kinase Binding Epithelial Cell Proliferation Regulation Of Cell Differentiation Regulation Of ERK1 And ERK2 Cascade MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process
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