Wiki-Pi
About
Search
People
Updates
Search
STAT3 and GHR
Number of citations of the paper that reports this interaction (PubMedID
8923468
)
0
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
STAT3
GHR
Description
signal transducer and activator of transcription 3
growth hormone receptor
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrial Inner Membrane
Cytosol
Plasma Membrane
Postsynaptic Density
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuronal Cell Body
Receptor Complex
Growth Hormone Receptor Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Chromatin DNA Binding
CCR5 Chemokine Receptor Binding
Nuclear Glucocorticoid Receptor Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Primary MiRNA Binding
LncRNA Binding
DNA-binding Transcription Factor Binding
Protein Sequestering Activity
RNA Sequestering Activity
Cytokine Receptor Activity
Growth Hormone Receptor Activity
Protein Binding
Lipid Binding
Peptide Hormone Binding
Growth Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cytokine Binding
Protein Tyrosine Kinase Activator Activity
SH2 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Proline-rich Region Binding
Protein Tyrosine Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Temperature Homeostasis
Response To Hypoxia
Eye Photoreceptor Cell Differentiation
Regulation Of Cytokine Production
Response To Ischemia
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Defense Response
Acute-phase Response
Inflammatory Response
Immune Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Gene Expression
Negative Regulation Of Autophagy
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Sexual Reproduction
Signal Transduction Involved In Regulation Of Gene Expression
Cell Differentiation
Positive Regulation Of Cell Migration
Intracellular Receptor Signaling Pathway
Response To Estradiol
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Hormone Stimulus
Leptin-mediated Signaling Pathway
Response To Cytokine
Somatic Stem Cell Population Maintenance
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-11-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Regulation Of Cell Population Proliferation
Glucose Homeostasis
Eating Behavior
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Peptide Hormone
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Leptin Stimulus
Response To Leptin
Response To Ethanol
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Angiogenesis
Negative Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Mitochondrial Membrane Permeability
Astrocyte Differentiation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Retinal Rod Cell Differentiation
Regulation Of Feeding Behavior
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
T-helper 17 Type Immune Response
T-helper 17 Cell Lineage Commitment
Positive Regulation Of Extracellular Matrix Disassembly
Inflammatory Response To Wounding
Energy Homeostasis
Cellular Response To Interleukin-17
Cell Surface Receptor Signaling Pathway Via STAT
Postsynapse To Nucleus Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Interleukin-10-mediated Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Cellular Response To Hypoxia
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of 3'-UTR-mediated MRNA Stabilization
Negative Regulation Of Primary MiRNA Processing
Negative Regulation Of Stem Cell Differentiation
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Neuron Migration
Endocytosis
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Response To Gravity
Response To Hormone
Hormone-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Receptor Internalization
Response To Food
Regulation Of Response To Nutrient Levels
Response To Estradiol
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Response To Cytokine
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cycloheximide
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Glucocorticoid
Cartilage Development Involved In Endochondral Bone Morphogenesis
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Response To Growth Hormone
Response To Interleukin-1
Pathways
Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signalling to STAT3
Signaling by ALK
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Leptin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Association of TriC/CCT with target proteins during biosynthesis
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Transcriptional regulation of granulopoiesis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
STAT3 nuclear events downstream of ALK signaling
Inactivation of CSF3 (G-CSF) signaling
Cytoprotection by HMOX1
Signaling by ALK fusions and activated point mutants
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
PKR-mediated signaling
Regulation of PD-L1(CD274) transcription
Prolactin receptor signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
ENMD-1198
OPB-111077
Somatotropin
Pegvisomant
Somatrem
Somapacitan
Lonapegsomatropin
Diseases
Oral cancer
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Apolipoprotein B levels (
32203549
)
Atopic dermatitis (
26482879
)
Autoimmune thyroid disease (
32581359
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Composite immunoglobulin trait (IgA/IgG) (
28628107
)
Crohn's disease (
18587394
28067908
23266558
21102463
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
30578418
)
Inflammatory bowel disease (
23128233
26278503
27569725
28067908
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Multiple sclerosis (
20159113
31604244
24076602
22190364
21833088
)
Myocardial infarction (
33532862
)
Psoriasis (
25903422
23143594
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
30054458
)
Ulcerative colitis (
28067908
)
Appendicular lean mass (
33097823
)
Blood protein levels (
30072576
)
Familial squamous cell lung carcinoma (
29924316
)
Heel bone mineral density (
30598549
)
Height (
25429064
28552196
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Iron status biomarkers (
19084217
)
Menarche (age at onset) (
25231870
)
Plasma renin activity levels (
29650764
)
Response to taxane treatment (docetaxel) (
23006423
)
Systemic lupus erythematosus (
18204098
)
Interacting Genes
214 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DSCAM
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GAS5
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFE2L2
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RNF31
RPA2
RPL11
RPRD1B
RPS6KA1
RPS6KA3
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TAB3
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
44 interacting genes:
AP2A1
BTRC
CISH
CUL1
CUL5
DUSP7
ELOB
ELOC
FBXO31
GH1
GH2
GRB10
GRB2
IRS1
JAK1
JAK2
NCOA6
NEDD8
PIK3R1
PIK3R2
PLCG1
PTPN1
PTPN11
PTPN13
PTPN2
PTPN3
PTPN6
PTPN9
PTPRB
PTPRH
RBX1
RNF7
SGTA
SHC1
SKP1
SOCS1
SOCS2
SOCS3
SRPK2
STAT3
STAT5A
STAT5B
STUB1
TYK2
Entrez ID
6774
2690
HPRD ID
00026
02971
Ensembl ID
ENSG00000168610
ENSG00000112964
Uniprot IDs
A0A7I2V395
A0A7I2V444
A0A7I2V4C8
A0A7I2V4R2
A0A7I2V4R3
A0A7I2V552
A0A7I2YQD2
A0A7I2YQR5
P40763
A0A087X0H5
A0A087X162
P10912
PDB IDs
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
1A22
1AXI
1HWG
1HWH
1KF9
2AEW
3HHR
5OEK
5OHD
6I5J
6I5N
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Metabolic Process
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Macromolecule Metabolic Process
Signal Transduction
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Regulation Of Multicellular Organismal Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Protein Kinase Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Developmental Process
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Phosphorylation
Regulation Of Signal Transduction
Positive Regulation Of DNA-templated Transcription
Response To Lipid
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Cell Differentiation
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Immune System Process
Response To Cytokine
Phosphorylation
Kinase Activity
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Response To Peptide
Cell Surface Receptor Signaling Pathway Via STAT
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Modification Process
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway Via STAT
Cytosol
Protein Dephosphorylation
Growth Hormone Receptor Binding
Protein Tyrosine Phosphatase Activity
Peptidyl-tyrosine Dephosphorylation
Signal Transduction
Protein Metabolic Process
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Macromolecule Metabolic Process
Cul5-RING Ubiquitin Ligase Complex
Dephosphorylation
Phosphoprotein Phosphatase Activity
Regulation Of Signal Transduction
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Cellular Response To Insulin Stimulus
Protein Ubiquitination
Insulin Receptor Binding
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Protein Modification By Small Protein Conjugation
Regulation Of Signaling
Regulation Of Cell Communication
Post-translational Protein Modification
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Regulation Of Cell Adhesion
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cytoplasm
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?