KDR and ITGB3

Number of citations of the paper that reports this interaction (PubMedID 10022831)
67

Data Source:
HPRD (in vivo)

		KDR	ITGB3
Description		kinase insert domain receptor	integrin subunit beta 3
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Receptor Complex Membrane Raft Anchoring Junction Cell Periphery Sorting Endosome	Ruffle Nucleus Nucleoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Filopodium Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Protein-containing Complex Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Melanosome Cell Projection Receptor Complex Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Alpha9-beta1 Integrin-ADAM8 Complex Synaptic Membrane Glycinergic Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Integrin Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Growth Factor Binding Vascular Endothelial Growth Factor Binding Identical Protein Binding Cadherin Binding Hsp90 Protein Binding	Virus Receptor Activity Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Protein Kinase C Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding Enzyme Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Maturation Endocardium Development Endothelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Mesenchymal Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Cell Differentiation Lung Development Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Embryonic Hemopoiesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Post-embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Calcium Ion Homeostasis Epithelial Tube Morphogenesis Blood Vessel Endothelial Cell Differentiation Vascular Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Stem Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Bone Development Cellular Response To Hydrogen Sulfide Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Vasculogenesis	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Leukocyte Migration Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Blood Coagulation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Smooth Muscle Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Negative Regulation Of Lipid Transport Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Wound Healing, Spreading Of Epidermal Cells Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Apoptotic Cell Clearance Regulation Of Bone Resorption Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Developmental Process Negative Chemotaxis Regulation Of Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Serotonin Uptake Angiogenesis Involved In Wound Healing Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Glomerular Mesangial Cell Proliferation Blood Coagulation, Fibrin Clot Formation Maintenance Of Postsynaptic Specialization Structure Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Trophoblast Cell Migration Regulation Of Extracellular Matrix Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization Integrin cell surface interactions VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Sorafenib Sunitinib 1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Cediranib Vatalanib XL999 TG-100801 XL820 CYC116 Ramucirumab Pegdinetanib RAF-265 Linifanib IMC-1C11 Semaxanib Pazopanib Midostaurin Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib Lenvatinib Nintedanib Tivozanib Fostamatinib Erdafitinib Foretinib Ripretinib Pralsetinib Olinvacimab	Abciximab Eptifibatide Antithymocyte immunoglobulin (rabbit) Levothyroxine Tirofiban Resveratrol Lefradafiban LM-609 Fradafiban Ferric maltol
Diseases			Allograft rejection Glanzmann thrombasthenia
GWAS		Blood protein levels ( 30072576) Endometriosis ( 28537267) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FVC) ( 30804560) Mosquito bite size ( 28199695) Peak expiratory flow ( 30804560) Serum VEGFR2 concentration ( 25411163) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 33713608) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		63 interacting genes: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CCDC88A CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 DUSP19 FBXO25 FBXW11 FLT1 FLT4 FRS2 FYN GABARAP GNA11 GNAQ GRB10 GRB2 HSP90AA1 ILKAP IQGAP1 ITGB3 KPNA4 MAPK1 NCK1 NRP1 P2RY2 PDCL3 PLCG1 PLCG2 PPM1A PPM1B PTPN11 PTPN12 PTPN6 PTPRR RASA1 SERPINF1 SH2D2A SHB SHC1 SHC2 SNCA SRC STAT1 STYX SYNGAP1 TIMP3 USP7 VEGFA VEGFC VEGFD YES1	50 interacting genes: AKT1 ANGPTL3 APP CAPN1 CD36 CDK1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGFR1 FGG FLNA FLNB FN1 GRIA2 HRAS ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR MAPK3 MIIP NID1 NUMB P2RY2 P4HB PDGFRA PDGFRB PDK1 PDPK1 PECAM1 PLA2G2A PLA2G4A PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		3791	3690
HPRD ID		01867	01428
Ensembl ID		ENSG00000128052	ENSG00000259207
Uniprot IDs		P35968	P05106
PDB IDs		1VR2 1Y6A 1Y6B 1YWN 2M59 2MET 2MEU 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 3WZD 3WZE 4AG8 4AGC 4AGD 4ASD 4ASE 5EW3 5OYJ 6GQO 6GQP 6GQQ 6XVJ 6XVK	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1S4X 1TYE 1U8C 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2N9Y 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4Z7N 4Z7O 4Z7Q 5HDB 6AVQ 6AVR 6AVU 6BXB 6BXF 6BXJ 6CKB 6MK0 6MSL 6MSU 6NAJ 6V4P 7KN0 7L8P 7LA4 7TCT 7TD8 7THO 7TMZ 7TPD 7U60 7U9F 7U9V 7UBR 7UCY 7UDG 7UDH 7UE0 7UFH 7UH8 7UJE 7UJK 7UK9 7UKO 7UKP 7UKT 8GCD 8GCE 8IJ5 8T2U 8T2V 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9AXL 9DEQ 9DER
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Cytoplasm Regulation Of Vasculature Development Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor 2 Binding Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Programmed Cell Death Response To Platelet-derived Growth Factor T Cell Costimulation Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Population Proliferation Cell Motility SH3 Domain Binding Developmental Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cytosol Ephrin Receptor Signaling Pathway Focal Adhesion Immune Response-activating Signaling Pathway Protein Dephosphorylation	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Focal Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Integrin-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cell Adhesion Integrin Binding Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell-substrate Adhesion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Angiogenesis Cell-matrix Adhesion Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Anchoring Junction Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction External Side Of Plasma Membrane Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Protein Autophosphorylation Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport
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