KDR and CSNK1D

Number of citations of the paper that reports this interaction (PMID 22711876)
8

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		KDR	CSNK1D
Gene Name		kinase insert domain receptor	casein kinase 1, delta
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Membrane Raft Sorting Endosome	Nucleus Golgi Apparatus Centrosome Spindle Cytosol Spindle Microtubule Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Hsp90 Protein Binding	Glycoprotein Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Peptide Binding Tau-protein Kinase Activity Phosphoprotein Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mesenchymal Cell Proliferation Endothelium Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Extracellular Matrix Organization Positive Regulation Of Cell Migration Embryonic Hemopoiesis Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of MAPK Cascade Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Cell Maturation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Focal Adhesion Assembly Calcium Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Spindle Assembly Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		VEGF binds to VEGFR leading to receptor dimerization EPHA-mediated growth cone collapse VEGF ligand-receptor interactions Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF EPH-Ephrin signaling Neurophilin interactions with VEGF and VEGFR Integrin cell surface interactions VEGFA-VEGFR2 Pathway	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs		Sorafenib Sunitinib N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N\'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA Pazopanib Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N\'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib
Diseases
GWAS
Protein-Protein Interactions		49 interactors: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 FBXO25 FBXW11 FIGF FLT1 FLT4 FRS2 FYN GNA11 GNAQ GRB10 GRB2 HSP90AA1 IQGAP1 ITGB3 NCK1 NRP1 P2RY2 PLCG1 PLCG2 PTPN11 PTPN6 RASA1 SH2D2A SHB SHC1 SHC2 SRC STAT1 SYNGAP1 TIMP3 UBC VEGFA VEGFC YES1	27 interactors: AKAP9 APP ARFGAP1 ATM BACE1 BRCA1 CDK5 CTNNB1 DVL1 DVL3 GJA1 HN1L KDR LURAP1 MAPT PER1 PER2 PER3 PPP1R14A PSEN2 SMAD2 SMAD3 SNAPIN SNCA TP53 TRIM9 YWHAZ
Entrez ID		3791	1453
HPRD ID		01867	02920
Ensembl ID		ENSG00000128052	ENSG00000141551
Uniprot IDs		P35968	H7BYT1 P48730
PDB IDs		1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE	3UYS 3UYT 3UZP 4HGT 4HNF 4KB8 4KBA 4KBC 4KBK
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Body Fluid Levels Response To Growth Factor Anatomical Structure Morphogenesis Response To Wounding Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Platelet Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process System Development Response To Organic Substance Cardiovascular System Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Anatomical Structure Development Cell Differentiation Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Leukocyte Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Blood Vessel Development Cellular Response To Peptide Positive Regulation Of Metabolic Process Angiogenesis	Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Signaling Positive Regulation Of Protein Metabolic Process Apoptotic Process Cell Communication Programmed Cell Death Regulation Of Binding Cell Death Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Embryo Development Establishment Of Organelle Localization Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Organelle Localization Regulation Of Cell Development Cell Development Negative Regulation Of Protein Metabolic Process Developmental Growth Cell-cell Signaling Regulation Of Organelle Organization Synapse Organization Regulation Of Cell Differentiation Embryonic Organ Development Growth Positive Regulation Of Metabolic Process Secretion By Cell Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Establishment Of Vesicle Localization Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Cellular Metabolic Process Vesicle Localization Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Synaptic Vesicle Transport Organelle Organization Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Difference) ?		accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Intersection) ?