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KDR and DNM2
Number of citations of the paper that reports this interaction (PubMedID
16049137
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
KDR
DNM2
Description
kinase insert domain receptor
dynamin 2
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Cytoplasmic Vesicle
Receptor Complex
Membrane Raft
Anchoring Junction
Cell Periphery
Sorting Endosome
Golgi Membrane
Phagocytic Cup
Uropod
Podosome
Cytoplasm
Endosome
Golgi Apparatus
Centrosome
Centriole
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Endomembrane System
Postsynaptic Density
Membrane
Clathrin-coated Vesicle
Growth Cone
Midbody
Endocytic Vesicle Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Cell Projection
Neuron Projection
Synapse
Postsynaptic Membrane
Recycling Endosome
Extracellular Exosome
Anchoring Junction
Presynapse
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Transferase Activity
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
Nucleotide Binding
GTPase Activity
Protein Binding
GTP Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Microtubule Binding
Hydrolase Activity
SH3 Domain Binding
Enzyme Binding
Biological Process
Angiogenesis
Ovarian Follicle Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Lymph Vessel Development
Positive Regulation Of Mesenchymal Cell Proliferation
Epithelial Cell Maturation
Endocardium Development
Endothelium Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Mesenchymal Cell Proliferation
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Cell Differentiation
Lung Development
Positive Regulation Of Cell Migration
Positive Regulation Of BMP Signaling Pathway
Embryonic Hemopoiesis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Surfactant Homeostasis
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Fate Commitment
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Lung Alveolus Development
Post-embryonic Camera-type Eye Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Mitochondrial Depolarization
Calcium Ion Homeostasis
Epithelial Tube Morphogenesis
Blood Vessel Endothelial Cell Differentiation
Vascular Wound Healing
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Stem Cell Proliferation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Bone Development
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Endothelial Cell Chemotaxis
Positive Regulation Of Vasculogenesis
G2/M Transition Of Mitotic Cell Cycle
Regulation Of DNA-templated Transcription
Post-Golgi Vesicle-mediated Transport
Endocytosis
Receptor-mediated Endocytosis
Phagocytosis
Autophagy
Centrosome Cycle
Signal Transduction
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Regulation Of Axon Extension
Receptor Internalization
Transferrin Transport
Positive Regulation Of Apoptotic Process
Stress Fiber Assembly
Positive Regulation Of DNA-templated Transcription
Synaptic Vesicle Transport
Neuron Projection Morphogenesis
Protein Polymerization
Membrane Organization
Actin Filament Bundle Organization
Membrane Tubulation
Vesicle Scission
Negative Regulation Of Membrane Tubulation
Pathways
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Toll Like Receptor 4 (TLR4) Cascade
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
NOSTRIN mediated eNOS trafficking
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
Clathrin-mediated endocytosis
NGF-stimulated transcription
Degradation of CDH1
Drugs
Sorafenib
Sunitinib
1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
Pegdinetanib
RAF-265
Linifanib
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Tivozanib
Fostamatinib
Erdafitinib
Foretinib
Ripretinib
Pralsetinib
Olinvacimab
Diseases
Centronuclear myopathy
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Blood protein levels (
30072576
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Bipolar disorder (
31043756
)
Height (
25429064
)
Hip circumference adjusted for BMI (
34021172
)
Hyperlipidemia (time to event) (
32589924
)
LDL cholesterol (
21347282
)
Waist-hip index (
34021172
)
Interacting Genes
63 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
KPNA4
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SNCA
SRC
STAT1
STYX
SYNGAP1
TIMP3
USP7
VEGFA
VEGFC
VEGFD
YES1
74 interacting genes:
AMPH
AOC1
AP2A1
APP
APPL1
ARX
ATF7IP
ATXN3
BAG3
BIN1
CCDC90B
CCR5
CCT7
CDK1
CEBPA
CTTN
DDX39B
DYNC1I1
DYNLL1
EIF3L
EPS15
FLAD1
FNBP1L
FXR1
FXR2
GDF9
GOLGA2
GRAP2
GRB2
HCK
HMGB1
ITSN1
KDR
MAN1B1
MANEA
MPHOSPH6
NTAQ1
PALS2
PCNT
PDE6G
PFN1
PPIB
PRKAA2
PSTPIP1
PTK2
PYGM
QARS1
RHOU
RNF8
RPS2
RWDD2B
SDCBP
SEC23A
SH3GL2
SH3GLB1
SH3RF1
SHANK1
SHANK2
SHANK3
SMARCA2
SNAPIN
SNX9
SPRY2
SRC
TIAM2
TRAF4
TRIP10
TYK2
UBASH3A
VAV1
WBP4
XIAP
ZBTB16
ZFAND6
Entrez ID
3791
1785
HPRD ID
01867
03852
Ensembl ID
ENSG00000128052
ENSG00000079805
Uniprot IDs
P35968
P50570
Q8N1K8
PDB IDs
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
6XVJ
6XVK
2YS1
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Anatomical Structure Formation Involved In Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Ephrin Receptor Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Angiogenesis
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of MAPK Cascade
Regulation Of Angiogenesis
Cytoplasm
Regulation Of Vasculature Development
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor 2 Binding
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Regulation Of Programmed Cell Death
Response To Platelet-derived Growth Factor
T Cell Costimulation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Cell Motility
SH3 Domain Binding
Developmental Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Cytosol
Ephrin Receptor Signaling Pathway
Focal Adhesion
Immune Response-activating Signaling Pathway
Protein Dephosphorylation
Cytosol
Endocytosis
Cytoplasm
Import Into Cell
Cadherin Binding
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Catabolic Process
Vesicle-mediated Transport
Identical Protein Binding
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Protein Metabolic Process
Regulation Of Endocytosis
Regulation Of Biological Quality
Vesicle-mediated Transport In Synapse
Regulation Of Cellular Component Organization
Regulation Of Cellular Component Size
Synaptic Receptor Adaptor Activity
Regulation Of Signaling
Dendritic Spine
Positive Regulation Of Organelle Organization
Clathrin-coated Pit
Synaptic Vesicle Endocytosis
Cellular Localization
Establishment Of Localization In Cell
Proline-rich Region Binding
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Communication
Organelle Organization
Presynaptic Endocytosis
Regulation Of MAPK Cascade
Phosphotyrosine Residue Binding
Positive Regulation Of Protein Polymerization
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Positive Regulation Of Protein-containing Complex Assembly
Synapse
Regulation Of Apoptotic Process
Regulation Of Long-term Neuronal Synaptic Plasticity
Intracellular Transport
Postsynaptic Endocytic Zone
Regulation Of Vesicle-mediated Transport
Positive Regulation Of Developmental Process
Regulation Of Developmental Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of JNK Cascade
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Negative Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Glutamatergic Synapse
Ionotropic Glutamate Receptor Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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