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KDR and SHC2
Number of citations of the paper that reports this interaction (PubMedID
10749680
)
46
Data Source:
BioGRID
(affinity chromatography technology, pull down, two hybrid, affinity chromatography technology)
HPRD
(in vivo, two hybrid, in vitro)
KDR
SHC2
Description
kinase insert domain receptor
SHC adaptor protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Cytoplasmic Vesicle
Receptor Complex
Membrane Raft
Anchoring Junction
Cell Periphery
Sorting Endosome
Cytosol
Plasma Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Transferase Activity
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Biological Process
Angiogenesis
Ovarian Follicle Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Lymph Vessel Development
Positive Regulation Of Mesenchymal Cell Proliferation
Epithelial Cell Maturation
Endocardium Development
Endothelium Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Mesenchymal Cell Proliferation
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Cell Differentiation
Lung Development
Positive Regulation Of Cell Migration
Positive Regulation Of BMP Signaling Pathway
Embryonic Hemopoiesis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Surfactant Homeostasis
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Fate Commitment
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Lung Alveolus Development
Post-embryonic Camera-type Eye Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Mitochondrial Depolarization
Calcium Ion Homeostasis
Epithelial Tube Morphogenesis
Blood Vessel Endothelial Cell Differentiation
Vascular Wound Healing
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Stem Cell Proliferation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Bone Development
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Endothelial Cell Chemotaxis
Positive Regulation Of Vasculogenesis
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Pathways
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Signalling to RAS
Signalling to RAS
VEGFA-VEGFR2 Pathway
RAF/MAP kinase cascade
Drugs
Sorafenib
Sunitinib
1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
Pegdinetanib
RAF-265
Linifanib
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Tivozanib
Fostamatinib
Erdafitinib
Foretinib
Ripretinib
Pralsetinib
Olinvacimab
Diseases
GWAS
Blood protein levels (
30072576
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
63 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
KPNA4
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SNCA
SRC
STAT1
STYX
SYNGAP1
TIMP3
USP7
VEGFA
VEGFC
VEGFD
YES1
12 interacting genes:
EGFR
ERBB2
ERBB3
ERBB4
FLT1
GRB2
KDR
KIT
MET
NTRK1
NTRK2
NTRK3
Entrez ID
3791
25759
HPRD ID
01867
19296
Ensembl ID
ENSG00000128052
ENSG00000129946
Uniprot IDs
P35968
P98077
PDB IDs
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
6XVJ
6XVK
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Anatomical Structure Formation Involved In Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Ephrin Receptor Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Angiogenesis
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of MAPK Cascade
Regulation Of Angiogenesis
Cytoplasm
Regulation Of Vasculature Development
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor 2 Binding
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Regulation Of Programmed Cell Death
Response To Platelet-derived Growth Factor
T Cell Costimulation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Cell Motility
SH3 Domain Binding
Developmental Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Cytosol
Ephrin Receptor Signaling Pathway
Focal Adhesion
Immune Response-activating Signaling Pathway
Protein Dephosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Receptor Complex
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Kinase Activity
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Neuron Differentiation
ATP Binding
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Growth Factor Binding
Protein Autophosphorylation
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Cell Differentiation
Nucleotide Binding
Transferase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Basal Plasma Membrane
Neurotrophin Receptor Activity
Neurotrophin Binding
Negative Regulation Of Programmed Cell Death
ERBB2 Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Protein Phosphorylation
ERBB Signaling Pathway
Phosphorylation
Regulation Of Programmed Cell Death
Cellular Developmental Process
Myelination
Axon Ensheathment
Positive Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphorylation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Cell Communication
Regulation Of Signaling
Cell Development
Positive Regulation Of Phosphate Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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