CASK and FCHSD2

Number of citations of the paper that reports this interaction (PubMedID 14627983)
0

Data Source:
HPRD (in vitro)

		CASK	FCHSD2
Description		calcium/calmodulin dependent serine protein kinase	FCH and double SH3 domains 2
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GO Annotations	Cellular Component	Basement Membrane Nucleus Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Nuclear Matrix Cell Junction Vesicle Presynaptic Membrane Synapse Ciliary Membrane Cell Periphery Schaffer Collateral - CA1 Synapse	Cytoplasm Plasma Membrane Clathrin-coated Pit Membrane Neuromuscular Junction Stereocilium Cell Projection Recycling Endosome Anchoring Junction Stereocilium Shaft
	Molecular Function	Nucleotide Binding GMP Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Neurexin Family Protein Binding Protein Serine Kinase Activity	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Cell Adhesion Intracellular Protein Localization Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Regulation Of Neurotransmitter Secretion Establishment Of Localization In Cell Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis	Endocytosis Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Membrane Organization Clathrin-dependent Endocytosis Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Formic acid Fostamatinib
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS			Albumin-globulin ratio ( 29403010) Crohn's disease ( 23266558 23850713) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein levels ( 29403010) Systemic lupus erythematosus ( 26663301 33272962)
Interacting Genes		90 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CIMIP1 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A RSPH1 SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TIAM1 TRIM22 TSPYL2 UBC WHRN WNT7B YWHAE	52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CIMIP6 CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
Entrez ID		8573	9873
HPRD ID		02164	13321
Ensembl ID		ENSG00000147044	ENSG00000137478
Uniprot IDs		A0A2R8YE77 A0A2U3TZM1 A0A7I2RJN6 O14936	O94868
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH 7OAI 7OAJ 7OAK 7OAL	2DL5 2DL7 6GBU
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Glutamatergic Synapse PDZ Domain Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Cell Projection Microtubule-based Process Intracellular Protein Localization Regulation Of Membrane Potential Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Neurotransmitter Secretion Learning Cellular Component Assembly Protein Localization To Cell Junction Social Behavior Cell Adhesion Presynaptic Membrane Microtubule Cytoskeleton Organization Protein Localization To Synapse Regulation Of Cytoskeleton Organization Cytoskeleton Organization Chemical Synaptic Transmission Neurotransmitter Transport Regulation Of System Process Cell-cell Junction Regulation Of Transport MPP7-DLG1-LIN7 Complex Trans-synaptic Signaling Learning Or Memory Regulation Of Monoatomic Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Exosomal Secretion Regulation Of Multicellular Organismal Process Voltage-gated Potassium Channel Complex Postsynaptic Membrane Plasma Membrane Neuromuscular Junction Presynapse Protein Kinase Binding Regulation Of Biological Quality Bicellular Tight Junction Protein Localization To Membrane	TPR Domain Binding Clathrin-dependent Synaptic Vesicle Endocytosis Cytoplasm
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