CASK and IL18

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CASK	IL18
Gene Name		calcium/calmodulin-dependent serine protein kinase (MAGUK family)	interleukin 18
Image
Gene Ontology Annotations	Cellular Component	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding	Cytokine Activity Protein Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus	MAPK Cascade Angiogenesis Inflammatory Response Immune Response Cell-cell Signaling Positive Regulation Of Gene Expression Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Chemokine Biosynthetic Process T-helper 1 Type Immune Response Type 2 Immune Response Interleukin-2 Biosynthetic Process Interferon-gamma Biosynthetic Process Positive Regulation Of Activated T Cell Proliferation Interleukin-13 Biosynthetic Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of NK T Cell Proliferation Cellular Response To Organic Cyclic Compound
Pathways		Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions	Signaling by Interleukins Interleukin-1 processing Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B	8 interactors: CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2
Entrez ID		8573	3606
HPRD ID		02164	02976
Ensembl ID		ENSG00000147044	ENSG00000150782
Uniprot IDs		O14936	Q14116
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC	1J0S 2VXT 3F62 4EEE 4EKX 4HJJ
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion	Execution Phase Of Apoptosis Immune System Process Immune Response T-helper 1 Type Immune Response Response To Cytokine Regulation Of Inflammatory Response Cellular Response To Organic Substance Positive Regulation Of Cytokine Production Interleukin-18-mediated Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Organic Substance Regulation Of Cytokine Production Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Tumor Necrosis Factor Positive Regulation Of Endopeptidase Activity Regulation Of Cell Adhesion Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Positive Regulation Of Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Adhesion Regulation Of Cysteine-type Endopeptidase Activity Glial Cell Apoptotic Process Response To Stress Regulation Of Apoptotic DNA Fragmentation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Apoptotic Process Adaptive Immune Response Programmed Cell Death Negative Regulation Of Keratinocyte Proliferation Cell Death Regulation Of T Cell Activation Death Regulation Of Cellular Process Positive Regulation Of Proteolysis Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Tagcloud ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Difference) ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	advance comprehensively doi genotyped haplotype household il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Intersection) ?