CASK and SMEK1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CASK	SMEK1
Gene Name		calcium/calmodulin-dependent serine protein kinase (MAGUK family)	SMEK homolog 1, suppressor of mek1 (Dictyostelium)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane	Nucleus Cytoplasm Microtubule Organizing Center Protein Phosphatase 4 Complex
	Molecular Function	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus	Protein Dephosphorylation Positive Regulation Of Gluconeogenesis
Pathways		Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B	3 interactors: CASK MAPK14 PPP4R2
Entrez ID		8573	55671
HPRD ID		02164	11176
Ensembl ID		ENSG00000147044	ENSG00000100796
Uniprot IDs		O14936	Q6IN85
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion	P38MAPK Cascade Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Brown Fat Cell Differentiation Posttranscriptional Regulation Of Gene Expression 3'-UTR-mediated MRNA Stabilization Stress-induced Premature Senescence Negative Regulation Of Keratinocyte Proliferation Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Calcium Ion Import Regulation Of Body Fluid Levels Hemopoiesis Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Positive Regulation Of Erythrocyte Differentiation Cellular Protein Modification Process Immune System Development Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Keratinocyte Proliferation Positive Regulation Of Transport Regulation Of Calcium Ion Import Cartilage Condensation Skeletal Muscle Tissue Regeneration MRNA Stabilization Regulation Of Double-strand Break Repair Cellular Senescence Positive Regulation Of Myotube Differentiation Calcium Ion Import Regulation Of Erythrocyte Differentiation Negative Regulation Of Cell-matrix Adhesion Lipopolysaccharide-mediated Signaling Pathway Regulation Of Myoblast Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Osteoclast Differentiation Myoblast Differentiation Cellular Protein Metabolic Process Negative Regulation Of Cell-substrate Adhesion Tissue Regeneration Toll-like Receptor 5 Signaling Pathway Regulation Of MRNA Stability Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Fat Cell Differentiation Regulation Of RNA Stability Nucleotide Phosphorylation Lactation
Tagcloud ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	4e activates actively additively arrests attempted bcl bp1 cascade cdk4 chemotherapeutic enhances gemcitabine initially luciferase modulators ovcar p16 p21 p27 p70s6k pdk1 pro promote promoted promotion suppresses tumorigenesis xl
Tagcloud (Difference) ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	4e activates actively additively arrests attempted bcl bp1 cascade cdk4 chemotherapeutic enhances gemcitabine initially luciferase modulators ovcar p16 p21 p27 p70s6k pdk1 pro promote promoted promotion suppresses tumorigenesis xl
Tagcloud (Intersection) ?