CASK and KCNJ2

Number of citations of the paper that reports this interaction (PMID 15024025)
29

Data Source:
HPRD (in vitro)

		CASK	KCNJ2
Gene Name		calcium/calmodulin-dependent serine protein kinase (MAGUK family)	potassium channel, inwardly rectifying subfamily J, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine
	Molecular Function	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions	GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulmonary function (interaction) ( 23284291) QT interval ( 19305409) Refractive error ( 23396134) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142)
Protein-Protein Interactions		60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B	14 interactors: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 INADL KCNJ11 KCNJ16 KCNJ4 KCNJ8 TRAK2
Entrez ID		8573	3759
HPRD ID		02164	02815
Ensembl ID		ENSG00000147044	ENSG00000123700
Uniprot IDs		O14936	P63252
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion	Receptor Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Protein Localization To Synapse Cell-cell Signaling Potassium Ion Import Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Potassium Ion Transmembrane Transport Cellular Protein Localization Potassium Ion Transport Nucleotide Metabolic Process Signaling Nucleobase-containing Small Molecule Metabolic Process Cell Communication Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cellular Process Metal Ion Transport Membrane Organization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Ion Transport Cell Junction Assembly Organophosphate Metabolic Process Chemotaxis Tight Junction Assembly Cation Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization Transport Negative Regulation Of Phosphatase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Regulation Of Protein Localization Positive Regulation Of Ion Transmembrane Transport Cell Projection Morphogenesis Cell Part Morphogenesis Protein Stabilization Axon Guidance Negative Regulation Of Transport
Tagcloud ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Difference) ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Intersection) ?