CASK and TSPYL2

Number of citations of the paper that reports this interaction (PMID 15066269)
22

Data Source:
HPRD (two hybrid, in vivo)

		CASK	TSPYL2
Gene Name		calcium/calmodulin-dependent serine protein kinase (MAGUK family)	TSPY-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Plasma Membrane
	Molecular Function	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding	RDNA Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus	Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Chromatin Modification Negative Regulation Of Cell Growth Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways		Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B	9 interactors: APTX CASK CCNB1 CDK1 CDK2 CDK4 COIL EEF1A1 GFI1B
Entrez ID		8573	64061
HPRD ID		02164	06713
Ensembl ID		ENSG00000147044	ENSG00000184205
Uniprot IDs		O14936	Q9H2G4
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion	G1/S Transition Of Mitotic Cell Cycle Response To Inorganic Substance Histone Phosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cell Division G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Ventricular Cardiac Muscle Cell Development Response To Toxic Substance Protein Phosphorylation Chromatin Modification Response To Reactive Oxygen Species Regulation Of Protein Ubiquitination Ventricular Cardiac Muscle Cell Differentiation Mitotic Cell Cycle Process Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Mitotic Nuclear Envelope Disassembly Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Heart Growth Phosphate-containing Compound Metabolic Process Nuclear Envelope Disassembly Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Chromosome Condensation Positive Regulation Of Organ Growth Mitotic Nuclear Division Cellular Nitrogen Compound Metabolic Process Response To Metal Ion Phosphorylation Regulation Of Cell Cycle Centrosome Cycle Regulation Of Heart Growth
Tagcloud ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	abolishes abrogates af1 bradyzoite bradyzoites cyst cysts disseminate gondii ip1 myoblasts myosin myotubes opportunistic persist polynucleated replicate replicating restrict skmcs sustain syncytial tachyzoite tachyzoites toxoplasma toxoplasmosis upregulate vigorous vigorously
Tagcloud (Difference) ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	abolishes abrogates af1 bradyzoite bradyzoites cyst cysts disseminate gondii ip1 myoblasts myosin myotubes opportunistic persist polynucleated replicate replicating restrict skmcs sustain syncytial tachyzoite tachyzoites toxoplasma toxoplasmosis upregulate vigorous vigorously
Tagcloud (Intersection) ?