CASK and NRXN3

Number of citations of the paper that reports this interaction (PMID 8786425)
97

Data Source:
HPRD (in vitro, two hybrid)

		CASK	NRXN3
Gene Name		calcium/calmodulin-dependent serine protein kinase (MAGUK family)	neurexin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane	Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding	Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus	Angiogenesis Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Synapse Maturation
Pathways		Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body mass index ( 20935630) Obesity ( 23563607 21552555) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist circumference ( 19557197)
Protein-Protein Interactions		60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B	5 interactors: CASK MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		8573	9369
HPRD ID		02164	08989
Ensembl ID		ENSG00000147044
Uniprot IDs		O14936	Q9HDB5 Q9Y4C0
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Terminal Button Organization Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Adhesion Synapse Assembly Regulation Of Ion Transmembrane Transport Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Postsynaptic Density Protein 95 Clustering Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Synapse Organization Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell-cell Signaling Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Ion Transmembrane Transport Single Organismal Cell-cell Adhesion Synaptic Transmission Regulation Of Dendrite Development Cellular Component Assembly Cytoskeletal Matrix Organization At Active Zone
Tagcloud ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?