FCHSD2

Name	FCH and double SH3 domains 2
Structure
Novel Interactors	1 novel interactors: PDE2A
Interactors	52 interactors: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CIMIP6 CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Clathrin-coated Pit Membrane Neuromuscular Junction Stereocilium Cell Projection Recycling Endosome Anchoring Junction Stereocilium Shaft
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Endocytosis Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Membrane Organization Clathrin-dependent Endocytosis Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
GWAS	Albumin-globulin ratio ( 29403010 ) Crohn's disease ( 23266558 23850713 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Health literacy ( 31250787 ) Nicotine dependence symptom count ( 25555482 ) Serum total protein levels ( 29403010 ) Systemic lupus erythematosus ( 26663301 33272962 )
Entrez ID	9873
HPRD ID	13321
Ensembl ID	ENSG00000137478
Uniprot IDs	O94868
PDB IDs	2DL5 2DL7 6GBU
GO Terms Enriched among Interactors ?	TPR Domain Binding Clathrin-dependent Synaptic Vesicle Endocytosis Cytoplasm