CASK and ATP2B4

Number of citations of the paper that reports this interaction (PubMedID 12511555)
0

Data Source:
HPRD (in vitro, in vivo)

		CASK	ATP2B4
Description		calcium/calmodulin dependent serine protein kinase	ATPase plasma membrane Ca2+ transporting 4
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GO Annotations	Cellular Component	Basement Membrane Nucleus Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Nuclear Matrix Cell Junction Vesicle Presynaptic Membrane Synapse Ciliary Membrane Cell Periphery Schaffer Collateral - CA1 Synapse	Mitochondrion Plasma Membrane Caveola Cilium Membrane Basolateral Plasma Membrane Z Disc T-tubule Motile Cilium Protein-containing Complex Ciliary Basal Body Sperm Flagellum Sarcolemma Cell Projection Intracellular Membrane-bounded Organelle Membrane Raft Presynaptic Active Zone Membrane Sperm Principal Piece Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GMP Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Neurexin Family Protein Binding Protein Serine Kinase Activity	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Sodium Channel Regulator Activity Protein Kinase Binding PDZ Domain Binding Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Cell Adhesion Intracellular Protein Localization Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Regulation Of Neurotransmitter Secretion Establishment Of Localization In Cell Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis	Neural Retina Development Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Spermatogenesis Negative Regulation Of Gene Expression Urinary Bladder Smooth Muscle Contraction Negative Regulation Of Angiogenesis Hippocampus Development Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytosolic Calcium Ion Concentration Response To Hydrostatic Pressure Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Transport Across Blood-brain Barrier Negative Regulation Of Arginine Catabolic Process Calcium Ion Export Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Regulation Of Cardiac Conduction Cellular Response To Acetylcholine
Pathways		Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs		Formic acid Fostamatinib	Ritodrine Halothane Desflurane Sevoflurane
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS			Appendicular lean mass ( 33097823) Breast size ( 22747683) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Glycated hemoglobin levels ( 34059833) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494 27863252) Malaria ( 22895189 31844061) Mean corpuscular hemoglobin concentration ( 23263863 27863252 32888494 28453575) Mean corpuscular volume ( 27863252 32888494) Monocyte count ( 32888494) Obstructive sleep apnea (average oxygen saturation during sleep) ( 26977737) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		90 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CIMIP1 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A RSPH1 SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TIAM1 TRIM22 TSPYL2 UBC WHRN WNT7B YWHAE	11 interacting genes: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBIN NOS1 PPP3CA RASSF1 SRC
Entrez ID		8573	493
HPRD ID		02164	00159
Ensembl ID		ENSG00000147044	ENSG00000058668
Uniprot IDs		A0A2R8YE77 A0A2U3TZM1 A0A7I2RJN6 O14936	P23634
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH 7OAI 7OAJ 7OAK 7OAL	1CFF 2KNE
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Glutamatergic Synapse PDZ Domain Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Cell Projection Microtubule-based Process Intracellular Protein Localization Regulation Of Membrane Potential Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Neurotransmitter Secretion Learning Cellular Component Assembly Protein Localization To Cell Junction Social Behavior Cell Adhesion Presynaptic Membrane Microtubule Cytoskeleton Organization Protein Localization To Synapse Regulation Of Cytoskeleton Organization Cytoskeleton Organization Chemical Synaptic Transmission Neurotransmitter Transport Regulation Of System Process Cell-cell Junction Regulation Of Transport MPP7-DLG1-LIN7 Complex Trans-synaptic Signaling Learning Or Memory Regulation Of Monoatomic Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Exosomal Secretion Regulation Of Multicellular Organismal Process Voltage-gated Potassium Channel Complex Postsynaptic Membrane Plasma Membrane Neuromuscular Junction Presynapse Protein Kinase Binding Regulation Of Biological Quality Bicellular Tight Junction Protein Localization To Membrane	Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Cell Adhesion GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity GDP Metabolic Process Protein Localization To Synapse Cell Junction Protein Localization To Cell Junction Basolateral Plasma Membrane Kinase Binding Postsynaptic Density Membrane GMP Metabolic Process Synaptic Signaling Regulation Of Biological Quality Positive Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Adherens Junction Cell-cell Junction Synapse Scaffold Protein Binding Regulation Of Transport Plasma Membrane Regulation Of Vesicle-mediated Transport Nucleoside Monophosphate Metabolic Process Postsynaptic Density Ribonucleoside Diphosphate Metabolic Process Regulation Of System Process Glutamatergic Synapse Nucleoside Diphosphate Metabolic Process Cell-cell Signaling Basement Membrane Juxtaparanode Region Of Axon Signaling Intracellular Protein Localization Cell Periphery Regulation Of Endocytosis Cell Communication Chemical Synaptic Transmission Protein Localization To Membrane Cellular Response To Potassium Ion Sarcolemma Neuron Projection Trans-synaptic Signaling Regulation Of Metal Ion Transport
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