CASK and MAPRE1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		CASK	MAPRE1
Description		calcium/calmodulin dependent serine protein kinase	microtubule associated protein RP/EB family member 1
Image
GO Annotations	Cellular Component	Basement Membrane Nucleus Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Nuclear Matrix Cell Junction Vesicle Presynaptic Membrane Synapse Ciliary Membrane Cell Periphery Schaffer Collateral - CA1 Synapse	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Cell Projection Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Astral Microtubule End Mitotic Spindle Microtubule
	Molecular Function	Nucleotide Binding GMP Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Neurexin Family Protein Binding Protein Serine Kinase Activity	RNA Binding Protein Binding Microtubule Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Cell Adhesion Intracellular Protein Localization Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Regulation Of Neurotransmitter Secretion Establishment Of Localization In Cell Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Intracellular Protein Localization Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Protein Localization To Mitotic Spindle Protein Localization To Astral Microtubule Non-motile Cilium Assembly
Pathways		Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Formic acid Fostamatinib
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS			Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		90 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CIMIP1 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A RSPH1 SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TIAM1 TRIM22 TSPYL2 UBC WHRN WNT7B YWHAE	50 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TUBA1A TUBB ZNF653
Entrez ID		8573	22919
HPRD ID		02164	04379
Ensembl ID		ENSG00000147044	ENSG00000101367
Uniprot IDs		A0A2R8YE77 A0A2U3TZM1 A0A7I2RJN6 O14936	Q15691
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH 7OAI 7OAJ 7OAK 7OAL	1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Glutamatergic Synapse PDZ Domain Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Cell Projection Microtubule-based Process Intracellular Protein Localization Regulation Of Membrane Potential Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Neurotransmitter Secretion Learning Cellular Component Assembly Protein Localization To Cell Junction Social Behavior Cell Adhesion Presynaptic Membrane Microtubule Cytoskeleton Organization Protein Localization To Synapse Regulation Of Cytoskeleton Organization Cytoskeleton Organization Chemical Synaptic Transmission Neurotransmitter Transport Regulation Of System Process Cell-cell Junction Regulation Of Transport MPP7-DLG1-LIN7 Complex Trans-synaptic Signaling Learning Or Memory Regulation Of Monoatomic Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Exosomal Secretion Regulation Of Multicellular Organismal Process Voltage-gated Potassium Channel Complex Postsynaptic Membrane Plasma Membrane Neuromuscular Junction Presynapse Protein Kinase Binding Regulation Of Biological Quality Bicellular Tight Junction Protein Localization To Membrane	Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Cytoskeleton Organization Regulation Of Cell Cycle Microtubule-based Process Establishment Of Mitotic Spindle Localization Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoplasm Microtubule Cytoskeleton Regulation Of Organelle Organization Establishment Of Organelle Localization Organelle Localization Mitotic Spindle Microtubule Plus-end Positive Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Establishment Of Spindle Localization Kinetochore Spindle Localization Centrosome Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Microtubule Binding Cellular Component Assembly Regulation Of Microtubule Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Cytosol Establishment Of Localization In Cell Establishment Of Spindle Orientation Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Metabolic Process Microtubule Plus-end Binding Spindle Perinuclear Region Of Cytoplasm Protein Kinase Binding Negative Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?