CASK and NPHS1

Number of citations of the paper that reports this interaction (PubMedID 15331416)
62

Data Source:
HPRD (in vivo)

		CASK	NPHS1
Description		calcium/calmodulin dependent serine protein kinase	NPHS1 adhesion molecule, nephrin
Image
GO Annotations	Cellular Component	Basement Membrane Nucleus Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Nuclear Matrix Cell Junction Vesicle Presynaptic Membrane Synapse Ciliary Membrane Cell Periphery Schaffer Collateral - CA1 Synapse	Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Slit Diaphragm Cell Projection Extracellular Exosome Cell Periphery
	Molecular Function	Nucleotide Binding GMP Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Neurexin Family Protein Binding Protein Serine Kinase Activity	Protein Binding Myosin Binding Cell Adhesion Molecule Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Cell Adhesion Intracellular Protein Localization Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Regulation Of Neurotransmitter Secretion Establishment Of Localization In Cell Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis	MAPK Cascade Cell Adhesion JNK Cascade Muscle Organ Development Skeletal Muscle Tissue Development Myoblast Fusion Gene Expression Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Protein Localization To Synapse Slit Diaphragm Assembly Podocyte Development Cell-cell Adhesion
Pathways		Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Nephrin family interactions Nephrin family interactions
Drugs		Formic acid Fostamatinib
Diseases		FG syndrome (FGS); Opitz-Kaveggia syndrome	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS
Interacting Genes		90 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CIMIP1 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A RSPH1 SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TIAM1 TRIM22 TSPYL2 UBC WHRN WNT7B YWHAE	11 interacting genes: CASK CD2AP FYN IQGAP1 KIRREL1 LYN NCK1 NCK2 NPHS2 SRC YES1
Entrez ID		8573	4868
HPRD ID		02164	04094
Ensembl ID		ENSG00000147044	ENSG00000161270
Uniprot IDs		A0A2R8YE77 A0A2U3TZM1 A0A7I2RJN6 O14936	O60500
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH 7OAI 7OAJ 7OAK 7OAL	4ZRT
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Glutamatergic Synapse PDZ Domain Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Cell Projection Microtubule-based Process Intracellular Protein Localization Regulation Of Membrane Potential Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Neurotransmitter Secretion Learning Cellular Component Assembly Protein Localization To Cell Junction Social Behavior Cell Adhesion Presynaptic Membrane Microtubule Cytoskeleton Organization Protein Localization To Synapse Regulation Of Cytoskeleton Organization Cytoskeleton Organization Chemical Synaptic Transmission Neurotransmitter Transport Regulation Of System Process Cell-cell Junction Regulation Of Transport MPP7-DLG1-LIN7 Complex Trans-synaptic Signaling Learning Or Memory Regulation Of Monoatomic Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Exosomal Secretion Regulation Of Multicellular Organismal Process Voltage-gated Potassium Channel Complex Postsynaptic Membrane Plasma Membrane Neuromuscular Junction Presynapse Protein Kinase Binding Regulation Of Biological Quality Bicellular Tight Junction Protein Localization To Membrane	Ephrin Receptor Signaling Pathway Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Actin Filament Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Complex Assembly Slit Diaphragm T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Motility Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Signaling Receptor Binding Immune Response-regulating Signaling Pathway Scaffold Protein Binding Activation Of Immune Response Response To Transforming Growth Factor Beta Regulation Of Cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cellular Response To Lectin Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Periphery Actin Filament Organization Positive Regulation Of Immune System Process Response To Growth Factor Protein Tyrosine Kinase Activity Regulation Of Cell Activation Transmembrane Transporter Binding Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress
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