AP3B1 and ARF6

Number of citations of the paper that reports this interaction (PubMedID 11926829)
0

Data Source:
HPRD (in vitro)

		AP3B1	ARF6
Description		adaptor related protein complex 3 subunit beta 1	ARF GTPase 6
Image
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Axon Cytoplasm Microvesicle	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Protein Targeting Protein Targeting To Lysosome Intracellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Lung Development Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Protein Modification Process MRNA Transcription By RNA Polymerase II Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development Melanosome Assembly	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development
Pathways		Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions	TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling
Drugs			5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases		Hermansky-Pudlak syndrome (HPS)
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Insulin resistance/response ( 21901158) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)	Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)
Interacting Genes		13 interacting genes: AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 GKAP1 SLC30A3	40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709
Entrez ID		8546	382
HPRD ID		04551	02714
Ensembl ID		ENSG00000132842	ENSG00000165527
Uniprot IDs		A0A0S2Z5J4 A0A8Q3SIM7 O00203	P62330
PDB IDs		9C58 9C59 9C5A 9C5B 9C5C	1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD
Enriched GO Terms of Interacting Partners?		Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Histone H2AXS139 Kinase Activity Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Mitotic Nuclear Division Nucleotide Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Mitotic Sister Chromatid Separation Protein Serine/threonine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Meiotic Sister Chromatid Cohesion Negative Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Cell Division Negative Regulation Of Cell Cycle Phase Transition Spindle DNA Strand Resection Involved In Replication Fork Processing Vesicle-mediated Transport Regulation Of Chromosome Organization Replicative Senescence Regulation Of Cellular Response To Heat Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Kinase Activity Negative Regulation Of B Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Organization Intracellular Protein Transport Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Outer Kinetochore Intracellular Protein Localization Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Segregation Kinase Activity Protein Localization To Site Of Double-strand Break Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Cellular Response To Gamma Radiation Chromosome Organization	Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion
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