AP3B1 and SLC30A3

Number of citations of the paper that reports this interaction (PMID 14657250)
29

Data Source:
HPRD (in vivo)

		AP3B1	SLC30A3
Gene Name		adaptor-related protein complex 3, beta 1 subunit	solute carrier family 30 (zinc transporter), member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane	Cytoplasm Endosome Late Endosome Integral Component Of Plasma Membrane Synaptic Vesicle Membrane Cell Junction Synaptic Vesicle Membrane Neuron Projection
	Molecular Function	Protein Phosphatase Binding GTP-dependent Protein Binding	Zinc Transporting ATPase Activity
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Blood Coagulation Anterograde Axon Cargo Transport Melanosome Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Positive Regulation Of NK T Cell Differentiation	Transport Positive Regulation Of Transport Transmembrane Transport Regulation Of Sequestering Of Zinc Ion Zinc Ion Transmembrane Transport
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Metal ion SLC transporters Zinc efflux and compartmentalization by the SLC30 family Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Zinc transporters SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Insulin resistance/response ( 21901158)
Protein-Protein Interactions		10 interactors: AP3S2 ARF1 ARF5 ARF6 ARR3 BUB1 BUB1B CLTC CSNK1A1 SLC30A3	4 interactors: AP3B1 AP3D1 AP3S1 NAALADL2
Entrez ID		8546	7781
HPRD ID		04551	11924
Ensembl ID		ENSG00000132842	ENSG00000115194
Uniprot IDs		E5RJ68 O00203	F5H3B7 Q99726
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Mitotic Nuclear Division Cell Division Protein Localization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Transport Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Chromosome Segregation Protein Transport Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Establishment Of Protein Localization Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Organelle Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Protein Localization Cellular Localization Small GTPase Mediated Signal Transduction Mitotic Cell Cycle Checkpoint Endocytosis Regulation Of Sequestering Of Zinc Ion Regulation Of Endocytosis Regulation Of Proteasomal Protein Catabolic Process Establishment Of Vesicle Localization Myeloid Cell Apoptotic Process Regulation Of Chromosome Organization Vesicle Localization	Anterograde Synaptic Vesicle Transport Anterograde Axon Cargo Transport Axon Cargo Transport Synaptic Vesicle Transport Positive Regulation Of NK T Cell Differentiation Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Establishment Of Vesicle Localization Vesicle Localization Melanosome Organization Microtubule-based Movement Pigment Granule Organization Establishment Of Organelle Localization Organelle Localization Positive Regulation Of Alpha-beta T Cell Differentiation Synaptic Transmission Cellular Pigmentation Microtubule-based Process Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Cell-cell Signaling Intracellular Protein Transport Pigmentation Regulation Of T Cell Differentiation Regulation Of Lymphocyte Differentiation Cellular Protein Localization Protein Transport Vesicle Organization Positive Regulation Of T Cell Activation Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Positive Regulation Of Homotypic Cell-cell Adhesion Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Intracellular Transport Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Regulation Of T Cell Activation Eye Pigment Biosynthetic Process Positive Regulation Of Cell Activation Protein Localization Establishment Of Localization In Cell Regulation Of Sequestering Of Zinc Ion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Eye Pigmentation Regulation Of Lymphocyte Activation Endosome To Melanosome Transport Pigment Granule Maturation
Tagcloud ?		amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca	absorption atomic carrier carriers cc concerning flame furnace graphite homozygotes kd micronutrient micronutrients modes mug polymorphisms rs11126936 rs561104 rs5854 rs5859 rs73924411 selenium selenoprotein sep15 solute spectrophotometry trace ultimately zinc
Tagcloud (Difference) ?		amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca	absorption atomic carrier carriers cc concerning flame furnace graphite homozygotes kd micronutrient micronutrients modes mug polymorphisms rs11126936 rs561104 rs5854 rs5859 rs73924411 selenium selenoprotein sep15 solute spectrophotometry trace ultimately zinc
Tagcloud (Intersection) ?