AP3B1 and ARR3

Number of citations: 0 (PubMedID 11877451)
Data Source: HPRD (in vitro, in vivo)

		AP3B1	ARR3
Name		adaptor related protein complex 3 subunit beta 1	arrestin 3
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Axon Cytoplasm Microvesicle	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cell Projection Synapse
	Molecular Function	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding	G Protein-coupled Receptor Binding Opsin Binding Protein Binding Phosphoprotein Binding
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Protein Targeting Protein Targeting To Lysosome Intracellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Lung Development Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Protein Modification Process MRNA Transcription By RNA Polymerase II Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development Melanosome Assembly	G Protein-coupled Receptor Internalization Endocytosis Signal Transduction Visual Perception
Pathways		Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions	None
Diseases		Hermansky-Pudlak syndrome (HPS)	None
GWAS		Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Body size at age 10 ( 32376654 ) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697 ) FEV1 ( 30804560 ) Hip circumference adjusted for BMI ( 34021172 ) Insulin resistance/response ( 21901158 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lung function (FEV1) ( 30061609 ) Lung function (FVC) ( 30061609 30804560 ) Metabolite levels ( 23823483 ) Red cell distribution width ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Triglycerides ( 26780889 ) Type 2 diabetes ( 31049640 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: CXADR FCGR2B RNGTT SSBP2 ZER1	None recorded
Interacting Genes		13 interacting genes: AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 GKAP1 SLC30A3	20 interacting genes: ADRB2 AP3B1 CAPNS1 CLTC CSNK2A1 DVL2 FSHR GNMT MAP2K7 MARCHF8 OPN1MW OPN4 PLK4 PTAFR RCOR2 RHO RNASE6 SRC ZBTB43 ZNF496
Entrez ID		8546	407
HPRD ID		04551	02358
Ensembl ID		ENSG00000132842	ENSG00000120500
Uniprot IDs		A0A0S2Z5J4 A0A8Q3SIM7 O00203	P36575
PDB IDs		9C58 9C59 9C5A 9C5B 9C5C	Not available
GO Terms Enriched among Interactors		Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Histone H2AXS139 Kinase Activity Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Mitotic Nuclear Division Nucleotide Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Mitotic Sister Chromatid Separation Protein Serine/threonine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Meiotic Sister Chromatid Cohesion Negative Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Cell Division Negative Regulation Of Cell Cycle Phase Transition Spindle DNA Strand Resection Involved In Replication Fork Processing Vesicle-mediated Transport Regulation Of Chromosome Organization Replicative Senescence Regulation Of Cellular Response To Heat Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Kinase Activity Negative Regulation Of B Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Organization Intracellular Protein Transport Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Outer Kinetochore Intracellular Protein Localization Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Segregation Kinase Activity Protein Localization To Site Of Double-strand Break Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Cellular Response To Gamma Radiation Chromosome Organization	Photoreceptor Activity G Protein-coupled Photoreceptor Activity Thermotaxis Photoreceptor Disc Membrane G Protein-coupled Receptor Activity Detection Of Visible Light Sperm Head Plasma Membrane Absorption Of Visible Light Phototransduction Detection Of Temperature Stimulus Involved In Thermoception 11-cis Retinal Binding G Protein-coupled Receptor Signaling Pathway Response To Temperature Stimulus Detection Of Light Stimulus Positive Regulation Of MAPK Cascade Lysosome Transcytosis Regulation Of Organelle Organization Cellular Response To Light Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Uterus Development Clathrin-coated Endocytic Vesicle Detection Of Temperature Stimulus Bone Resorption Detection Of Abiotic Stimulus Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Light Stimulus Enzyme Binding Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Vacuolar Transport Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Bone Remodeling Regulation Of Bone Resorption Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Radiation Rod Bipolar Cell Differentiation RNA Polymerase III General Transcription Initiation Factor Binding Glycine N-methyltransferase Activity Positive Regulation Of ERK1 And ERK2 Cascade Visual Perception Sensory Perception Of Light Stimulus Regulation Of Macroautophagy Response To Radiation Protein Targeting To Vacuole Vasodilation Fc Receptor Signaling Pathway