AP3B1 and ARR3

Number of citations of the paper that reports this interaction (PMID 11877451)
12

Data Source:
HPRD (in vitro, in vivo)

		AP3B1	ARR3
Gene Name		adaptor-related protein complex 3, beta 1 subunit	arrestin 3, retinal (X-arrestin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Synapse
	Molecular Function	Protein Phosphatase Binding GTP-dependent Protein Binding	Opsin Binding Protein Binding Phosphoprotein Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Blood Coagulation Anterograde Axon Cargo Transport Melanosome Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Positive Regulation Of NK T Cell Differentiation	Regulation Of Protein Phosphorylation Endocytosis Signal Transduction Visual Perception
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Insulin resistance/response ( 21901158)
Protein-Protein Interactions		10 interactors: AP3S2 ARF1 ARF5 ARF6 ARR3 BUB1 BUB1B CLTC CSNK1A1 SLC30A3	23 interactors: ADRB2 AP3B1 CAPNS1 CLTC CSNK2A1 CSNK2A2 CYTH1 DVL2 FSHR GNMT MAP2K7 OPN1MW OPN4 PARK2 PLK4 PTAFR PTGDS RCOR2 RHO RNASE6 SRC ZBTB43 ZNF496
Entrez ID		8546	407
HPRD ID		04551	02358
Ensembl ID		ENSG00000132842	ENSG00000120500
Uniprot IDs		E5RJ68 O00203	P36575
PDB IDs			1XEH 2A34
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Mitotic Nuclear Division Cell Division Protein Localization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Transport Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Chromosome Segregation Protein Transport Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Establishment Of Protein Localization Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Organelle Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Protein Localization Cellular Localization Small GTPase Mediated Signal Transduction Mitotic Cell Cycle Checkpoint Endocytosis Regulation Of Sequestering Of Zinc Ion Regulation Of Endocytosis Regulation Of Proteasomal Protein Catabolic Process Establishment Of Vesicle Localization Myeloid Cell Apoptotic Process Regulation Of Chromosome Organization Vesicle Localization	Protein-chromophore Linkage Regulation Of Carbohydrate Metabolic Process Response To External Stimulus Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Phototransduction, Visible Light Detection Of Visible Light Phototransduction Detection Of Light Stimulus Regulation Of Glucose Metabolic Process Regulation Of MAPK Cascade Response To Light Stimulus Positive Regulation Of Organelle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Rhodopsin Mediated Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Response To Abiotic Stimulus Cellular Metabolic Process Regulation Of JNK Cascade Bone Resorption G-protein Coupled Receptor Signaling Pathway Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Signaling Mitotic Spindle Checkpoint Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Chromosome Segregation Regulation Of Kinase Activity Cell Communication Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Lysosomal Transport Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Red, Far-red Light Phototransduction Regulation Of Cell Cycle Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Cellular Process
Tagcloud ?		amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca	arr2 arrestins arrs distributed gpcr gpcrs grk grk2 grk5 grk6 grks innate macrophages mechanistically modify responsiveness surprisingly talk tlr2 tlr3 tlr4 tlrs toll transcriptionally translational ubiquitously uncover vital
Tagcloud (Difference) ?		amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca	arr2 arrestins arrs distributed gpcr gpcrs grk grk2 grk5 grk6 grks innate macrophages mechanistically modify responsiveness surprisingly talk tlr2 tlr3 tlr4 tlrs toll transcriptionally translational ubiquitously uncover vital
Tagcloud (Intersection) ?