AP3B1 and BUB1B

Number of citations of the paper that reports this interaction (PMID 12419313)
4

Data Source:
HPRD (two hybrid)

		AP3B1	BUB1B
Gene Name		adaptor-related protein complex 3, beta 1 subunit	BUB1 mitotic checkpoint serine/threonine kinase B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Cytosol Perinuclear Region Of Cytoplasm Spindle Midzone
	Molecular Function	Protein Phosphatase Binding GTP-dependent Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Blood Coagulation Anterograde Axon Cargo Transport Melanosome Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Positive Regulation Of NK T Cell Differentiation	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Kinetochore Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Insulin resistance/response ( 21901158)
Protein-Protein Interactions		10 interactors: AP3S2 ARF1 ARF5 ARF6 ARR3 BUB1 BUB1B CLTC CSNK1A1 SLC30A3	21 interactors: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB1 BUB3 CASC5 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FZR1 HDAC1 MAP3K4 SNCG TP73
Entrez ID		8546	701
HPRD ID		04551	04176
Ensembl ID		ENSG00000132842	ENSG00000156970
Uniprot IDs		E5RJ68 O00203	O60566
PDB IDs			2WVI 3SI5 4GGD
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Mitotic Nuclear Division Cell Division Protein Localization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Transport Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Chromosome Segregation Protein Transport Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Establishment Of Protein Localization Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Organelle Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Protein Localization Cellular Localization Small GTPase Mediated Signal Transduction Mitotic Cell Cycle Checkpoint Endocytosis Regulation Of Sequestering Of Zinc Ion Regulation Of Endocytosis Regulation Of Proteasomal Protein Catabolic Process Establishment Of Vesicle Localization Myeloid Cell Apoptotic Process Regulation Of Chromosome Organization Vesicle Localization	Spindle Assembly Checkpoint Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Cell Cycle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Cell Division Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Cell Division Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca	accompanying bubr1 deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle
Tagcloud (Difference) ?		amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca	accompanying bubr1 deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle
Tagcloud (Intersection) ?