AP3B1 and BUB1B

Number of citations of the paper that reports this interaction (PubMedID 12419313)
0

Data Source:
HPRD (two hybrid)

		AP3B1	BUB1B
Description		adaptor related protein complex 3 subunit beta 1	BUB1 mitotic checkpoint serine/threonine kinase B
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GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Axon Cytoplasm Microvesicle	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Protein Targeting Protein Targeting To Lysosome Intracellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Lung Development Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Protein Modification Process MRNA Transcription By RNA Polymerase II Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development Melanosome Assembly	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region
Pathways		Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Hermansky-Pudlak syndrome (HPS)
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Insulin resistance/response ( 21901158) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)	Chronic lymphocytic leukemia ( 24292274 28165464)
Interacting Genes		13 interacting genes: AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 GKAP1 SLC30A3	31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13
Entrez ID		8546	701
HPRD ID		04551	04176
Ensembl ID		ENSG00000132842	ENSG00000156970
Uniprot IDs		A0A0S2Z5J4 A0A8Q3SIM7 O00203	O60566
PDB IDs		9C58 9C59 9C5A 9C5B 9C5C	2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?		Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Histone H2AXS139 Kinase Activity Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Mitotic Nuclear Division Nucleotide Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Mitotic Sister Chromatid Separation Protein Serine/threonine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Meiotic Sister Chromatid Cohesion Negative Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Cell Division Negative Regulation Of Cell Cycle Phase Transition Spindle DNA Strand Resection Involved In Replication Fork Processing Vesicle-mediated Transport Regulation Of Chromosome Organization Replicative Senescence Regulation Of Cellular Response To Heat Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Kinase Activity Negative Regulation Of B Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Organization Intracellular Protein Transport Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Outer Kinetochore Intracellular Protein Localization Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Segregation Kinase Activity Protein Localization To Site Of Double-strand Break Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Cellular Response To Gamma Radiation Chromosome Organization	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
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