RBM17 and LNX2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		RBM17	LNX2
Description		RNA binding motif protein 17	ligand of numb-protein X 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Protein-containing Complex	Plasma Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Brooding (response to stress) ( 30886212) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Multiple sclerosis ( 24076602) Soluble interleukin-2 receptor subunit alpha ( 26293465) Vitiligo ( 20410501)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		33 interacting genes: APBB1 C6orf47 CCDC170 CCHCR1 CEBPA CEP55 CSNK2A1 CWC15 FAM9B GOLGA2 HINFP HSF2BP IQCN LNX2 MIR106B MIR107 MIR128-1 MIR155 MIR21 MIR25 MIRLET7A2 MIRLET7G MIRLET7I OGT PPP1R12C PRC1 QRICH1 RBFOX2 SAP30BP SAT1 SF1 SF3B1 TNS3	90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581
Entrez ID		84991	222484
HPRD ID		09501	10042
Ensembl ID		ENSG00000134453	ENSG00000139517
Uniprot IDs		Q5W009 Q96I25	Q8N448
PDB IDs		2PE8 2PEH 5LSO 6HIP	2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT
Enriched GO Terms of Interacting Partners?		RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation Extracellular Vesicle Regulation Of Rac Protein Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Fat Cell Differentiation Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Cytokine Production Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Sin3-type Complex Negative Regulation Of Developmental Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Necroptotic Process U11/U12 SnRNP Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Lipoprotein Transport Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation	Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm
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