RBM17 and MIRLET7G

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		RBM17	MIRLET7G
Description		RNA binding motif protein 17	microRNA let-7g
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Protein-containing Complex	Extracellular Space RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of SMAD Protein Signal Transduction Cellular Response To Glucose Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Brooding (response to stress) ( 30886212) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Multiple sclerosis ( 24076602) Soluble interleukin-2 receptor subunit alpha ( 26293465) Vitiligo ( 20410501)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 23974872)
Interacting Genes		33 interacting genes: APBB1 C6orf47 CCDC170 CCHCR1 CEBPA CEP55 CSNK2A1 CWC15 FAM9B GOLGA2 HINFP HSF2BP IQCN LNX2 MIR106B MIR107 MIR128-1 MIR155 MIR21 MIR25 MIRLET7A2 MIRLET7G MIRLET7I OGT PPP1R12C PRC1 QRICH1 RBFOX2 SAP30BP SAT1 SF1 SF3B1 TNS3	116 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM17 RBM4 RBM4B RBM5 RBM6 RBMS1 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR
Entrez ID		84991	406890
HPRD ID		09501
Ensembl ID		ENSG00000134453	ENSG00000199150
Uniprot IDs		Q5W009 Q96I25
PDB IDs		2PE8 2PEH 5LSO 6HIP
Enriched GO Terms of Interacting Partners?		RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation Extracellular Vesicle Regulation Of Rac Protein Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Fat Cell Differentiation Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Cytokine Production Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Sin3-type Complex Negative Regulation Of Developmental Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Necroptotic Process U11/U12 SnRNP Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Lipoprotein Transport Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation	RNA Binding RNA Processing Nucleic Acid Binding RNA Metabolic Process MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Nucleus Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Translation MRNA 3'-UTR Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of RNA Stability Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process U2 SnRNP RNA Stabilization MRNA Stabilization Negative Regulation Of Translation Regulation Of Metabolic Process MiRNA Processing Protein-RNA Complex Assembly TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity U2-type Prespliceosome Assembly Negative Regulation Of Macromolecule Metabolic Process
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