RBM17 and CCDC170

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBM17	CCDC170
Description		RNA binding motif protein 17	coiled-coil domain containing 170
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Protein-containing Complex	Golgi Apparatus Cell Junction Ciliary Basal Body
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Protein Binding Microtubule Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	Microtubule Cytoskeleton Organization
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Brooding (response to stress) ( 30886212) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Multiple sclerosis ( 24076602) Soluble interleukin-2 receptor subunit alpha ( 26293465) Vitiligo ( 20410501)	Bone mineral density (spine) ( 26911590) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 31757997) Breast size ( 27182965 29855537) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometriosis ( 28537267) Eosinophil count ( 32888494) Fractures ( 30598549) Heel bone mineral density ( 31453325 30598549 30048462 28869591) Heel bone mineral density variance ( 31453325) Lymphocyte count ( 32888494) Number of sexual partners ( 30643258) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		33 interacting genes: APBB1 C6orf47 CCDC170 CCHCR1 CEBPA CEP55 CSNK2A1 CWC15 FAM9B GOLGA2 HINFP HSF2BP IQCN LNX2 MIR106B MIR107 MIR128-1 MIR155 MIR21 MIR25 MIRLET7A2 MIRLET7G MIRLET7I OGT PPP1R12C PRC1 QRICH1 RBFOX2 SAP30BP SAT1 SF1 SF3B1 TNS3	2 interacting genes: CCNH RBM17
Entrez ID		84991	80129
HPRD ID		09501	10797
Ensembl ID		ENSG00000134453	ENSG00000120262
Uniprot IDs		Q5W009 Q96I25	Q8IYT3
PDB IDs		2PE8 2PEH 5LSO 6HIP
Enriched GO Terms of Interacting Partners?		RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation Extracellular Vesicle Regulation Of Rac Protein Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Fat Cell Differentiation Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Gene Expression MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Cytokine Production Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Sin3-type Complex Negative Regulation Of Developmental Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Spermidine Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Necroptotic Process U11/U12 SnRNP Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Lipoprotein Transport Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation	CAK-ERCC2 Complex Transcription Factor TFIIK Complex Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex MRNA Cis Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II General Transcription Initiation Factor Activity Male Germ Cell Nucleus Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Metabolic Process DNA-templated Transcription Initiation
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