SPATA22 and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		SPATA22	PRMT6
Description		spermatogenesis associated 22	protein arginine methyltransferase 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Meiotic DNA Repair Synthesis Homologous Chromosome Pairing At Meiosis Gamete Generation Fertilization Spermatocyte Division Meiotic Cell Cycle Regulation Of Meiotic Cell Cycle Reproductive System Development	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Caudal middle frontal gyrus volume ( 31530798)	Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		7 interacting genes: ECT2 FAM107A GOLGA2 HSF2BP KDM1A PRMT6 VHL	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		84690	55170
HPRD ID		14862	10505
Ensembl ID		ENSG00000141255	ENSG00000198890
Uniprot IDs		A0A140VJV9 B4DHW8 F5GWB9 Q8NHS9	Q96LA8
PDB IDs			4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Response To Ionizing Radiation Negative Regulation Of Catabolic Process Histone H2AR3 Methyltransferase Activity Negative Regulation Of Autophagy Positive Regulation Of Protein Ubiquitination Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Centralspindlin Complex Positive Regulation Of Post-translational Protein Modification Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Mitotic Spindle Response To Ionizing Radiation Positive Regulation Of Mitotic Cytokinetic Process Protein Homooligomerization Regulation Of Primary Metabolic Process Cellular Response To Radiation Cellular Response To Stress Cell Morphogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Glycosylation Regulation Of Protein Glycosylation Golgi Disassembly DNA-binding Transcription Factor Binding Female Meiosis I Regulation Of Protein Ubiquitination Response To Fungicide MRF Binding Guanine Metabolic Process Protein Demethylase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Positive Regulation Of Macromolecule Metabolic Process Transcription Elongation Factor Activity Histone H3K4 Demethylase Activity Positive Regulation Of Cell Differentiation Golgi Ribbon Formation Importin-alpha Family Protein Binding Double-strand Break Repair Involved In Meiotic Recombination Regulation Of Post-translational Protein Modification Histone H3K9 Demethylase Activity Protein-arginine N-methyltransferase Activity	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus
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