PDK4 and REEP5

Data Source: HiPPIP (Novel)

		PDK4	REEP5
Name		pyruvate dehydrogenase kinase 4	receptor accessory protein 5
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding
	Biological Process	Regulation Of PH Insulin Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Stress Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Response To Starvation Regulation Of Bone Resorption Regulation Of Fatty Acid Oxidation Cellular Response To Fatty Acid Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis	Endoplasmic Reticulum Organization Regulation Of Intracellular Transport Endoplasmic Reticulum Membrane Organization
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	None
Drugs		Tretinoin 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol	None
GWAS		Refractive error ( 32231278 )	Attention deficit hyperactivity disorder ( 18839057 ) Daytime nap ( 33568662 ) Reaction time ( 29844566 )
Novel Interactors		1 novel interactors: REEP5	9 novel interactors: CD14 CPOX EDC3 GPX3 HBEGF LGR5 PDK4 PDLIM3 TENT4A
Interacting Genes		4 interacting genes: DLAT PDHA1 PLEKHF2 TRIM63	13 interacting genes: ABHD4 ARFGAP1 ARFIP2 CHRM5 GTF2H1 NUDT3 PBX3 PITPNC1 RAB5B RABAC1 RGS2 SNX1 VKORC1
Entrez ID		5166	7905
HPRD ID		03957	15918
Ensembl ID		ENSG00000004799	ENSG00000129625
Uniprot IDs		A4D1H4 Q16654	Q00765
PDB IDs		2E0A 2ZDX 2ZDY 2ZKJ 3D2R 7EAT 7EBB 7EBG	Not available
GO Terms Enriched among Interactors		Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Pyruvate Metabolic Process Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Dihydrolipoyllysine-residue Acetyltransferase Activity Glucose Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Amide Biosynthetic Process Hexose Metabolic Process Pyruvate Dehydrogenase (acetyl-transferring) Activity Monosaccharide Metabolic Process Skeletal Muscle Atrophy Purine-containing Compound Biosynthetic Process Pyruvate Catabolic Process Sulfur Compound Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Skeletal Muscle Adaptation Striated Muscle Atrophy Nucleoside Phosphate Biosynthetic Process Muscle Atrophy Titin Binding Contractile Muscle Fiber Endoplasmic Reticulum Membrane Organization Acetyltransferase Activity Mitochondrial Matrix Carbohydrate Metabolic Process Negative Regulation Of Glycolytic Process Endoplasmic Reticulum Tubular Network Monocarboxylic Acid Metabolic Process Purine-containing Compound Metabolic Process Catalytic Complex M Band Negative Regulation Of ATP Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Sarcoplasmic Reticulum Membrane Response To Electrical Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy	None