PDK4 and PDHA1

Number of citations of the paper that reports this interaction (PMID 12676647)
68

Data Source:
HPRD (in vitro)

		PDK4	PDHA1
Gene Name		pyruvate dehydrogenase kinase, isozyme 4	pyruvate dehydrogenase (lipoamide) alpha 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Nucleus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Response To Starvation Cellular Metabolic Process Small Molecule Metabolic Process Regulation Of Bone Resorption Regulation Of Fatty Acid Oxidation Cellular Response To Fatty Acid Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Glycolytic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		3 interactors: DLAT PDHA1 TRIM63	8 interactors: DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		5166	5160
HPRD ID		03957	02420
Ensembl ID		ENSG00000004799	ENSG00000131828
Uniprot IDs		A4D1H4 Q16654	P08559
PDB IDs		2E0A 2ZDX 2ZDY 2ZKJ 3D2R	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Glucose Metabolic Process Cellular Respiration Hexose Metabolic Process Monosaccharide Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Skeletal Muscle Atrophy Striated Muscle Atrophy Acetyl-CoA Biosynthetic Process Muscle Atrophy Generation Of Precursor Metabolites And Energy Skeletal Muscle Adaptation Regulation Of Cellular Ketone Metabolic Process Monocarboxylic Acid Metabolic Process Acetyl-CoA Metabolic Process Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Carboxylic Acid Metabolic Process Response To Electrical Stimulus Carbohydrate Metabolic Process Cellular Response To Glucocorticoid Stimulus Organic Acid Metabolic Process Cellular Response To Corticosteroid Stimulus Acyl-CoA Metabolic Process Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Oxidation-reduction Process Glycolytic Process Catabolic Process Coenzyme Biosynthetic Process Carbohydrate Catabolic Process Response To Glucocorticoid Response To Corticosteroid Cellular Response To Steroid Hormone Stimulus	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Insulin Receptor Signaling Pathway Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cellular Response To Oxygen Levels Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Response To Hormone Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration Cellular Response To Acid Chemical Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process
Tagcloud ?		bioinformatic desaturation diabesity discriminant dock1 elutriated ether fam126a gnptab goes granulocytes klf4 lipidome lipidomic monocyte mufa nfy pe peroxisomal phagocytic plasmalogen plasmalogens pls pufa rhm rnf96 silico squares transcriptomic	coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Difference) ?		bioinformatic desaturation diabesity discriminant dock1 elutriated ether fam126a gnptab goes granulocytes klf4 lipidome lipidomic monocyte mufa nfy pe peroxisomal phagocytic plasmalogen plasmalogens pls pufa rhm rnf96 silico squares transcriptomic	coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Intersection) ?