E2F1 and RARA

Number of citations of the paper that reports this interaction (PubMedID 24608861)
50

Data Source:
BioGRID (affinity chromatography technology, pull down)

		E2F1	RARA
Description		E2F transcription factor 1	retinoic acid receptor alpha
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Protein-containing Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding Protein Dimerization Activity Molecular Adaptor Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	MRNA Regulatory Element Binding Translation Repressor Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Transcription Coactivator Binding Retinoic Acid Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Histone Deacetylase Binding Protein Kinase B Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Checkpoint Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Anoikis Negative Regulation Of DNA Binding Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Regulation Of Cell Cycle Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Fat Cell Proliferation Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Protein Phosphorylation Germ Cell Development Spermatogenesis Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Translation Hippocampus Development Cell Differentiation Prostate Gland Development Regulation Of Granulocyte Differentiation Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Cytokine Multicellular Organism Growth MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Response To Ethanol Negative Regulation Of Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Ventricular Cardiac Muscle Cell Differentiation Sertoli Cell Fate Commitment Limb Development Face Development Bone Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Estrogen Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of MiRNA Transcription
Pathways		Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis TGFBR3 expression
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550 Trifarotene
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Acute myeloid leukemia (AML)
GWAS		Heel bone mineral density ( 30598549) Height ( 31562340) Waist circumference adjusted for body mass index ( 34021172)	Asthma ( 31619474)
Interacting Genes		83 interacting genes: ARID3A ATAD2 ATM ATR BIN1 BIRC2 BRCA1 BRD2 BRMS1 BTRC CCNA1 CCNA2 CCNF CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 CUL2 DDB2 DIABLO E2F6 EP300 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM4 MGA MNAT1 MTA1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NFKB1 NPDC1 NRIP1 NSMCE3 PARP1 PHB1 PKIB PRDM2 PURA RARA RB1 RBL1 RNF126 RNF144A SERTAD2 SETD7 SIRT1 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 SZRD1P1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP UBE3A UCHL5 VHL YWHAQ	96 interacting genes: ACTN4 AKT1 ALOX15B ALX1 ARID1A ARID5A BAG1 BBS4 BMAL1 BTG1 CCND3 CCNDBP1 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FGFR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MCRS1 MDM2 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2C1 NR2E3 NR3C1 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PLEKHF2 PML PNRC2 POU2F1 PRAME PRDX6 PRKCA PSMC5 RXRA RXRB RXRG S100A3 SIRT1 SMARCD3 SNW1 SP1 SPEN SRC SRF STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIM24 TRIP4 UBE3A UBQLN1 UBR5 USP7 ZBTB16
Entrez ID		1869	5914
HPRD ID		01806	06769
Ensembl ID		ENSG00000101412	ENSG00000131759
Uniprot IDs		Q01094 Q9BSD8	A8K840 A8MUP8 F1D8N9 P10276 Q6I9R7
PDB IDs		1H24 1O9K 2AZE 5M9N 5M9O 6G0P 6ULS 9CB3	1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM 5K13 6XWG 7AOS 7APO 7QAA 7WQQ 9GFE 9GFI
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Chromatin Organization DNA Damage Response Chromatin Remodeling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Repair G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Cell Cycle G1/S Phase Transition Chromatin Cellular Response To Stress Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of DNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death	Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Nuclear Retinoic Acid Receptor Binding Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Response To Hormone Nuclear Retinoid X Receptor Binding Rhythmic Process Transcription Regulator Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription Coactivator Activity Retinoic Acid Receptor Signaling Pathway Sequence-specific DNA Binding Regulation Of Developmental Process Chromatin Binding Nuclear Estrogen Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding
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