Wiki-Pi
About
Search
People
Updates
Search
E2F1 and ATR
Number of citations of the paper that reports this interaction (PubMedID
11459832
)
53
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro)
E2F1
ATR
Description
E2F transcription factor 1
ATR checkpoint kinase
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Chromosome
Golgi Apparatus
PML Body
ATR-ATRIP Complex
Site Of DNA Damage
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Molecular Adaptor Activity
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Histone H2AXS139 Kinase Activity
Protein Serine Kinase Activity
Biological Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Forebrain Development
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Regulation Of Cell Cycle
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Telomere Maintenance
Nucleobase-containing Compound Metabolic Process
DNA Replication
DNA Repair
Double-strand Break Repair
Chromatin Remodeling
DNA Damage Response
Nuclear Envelope Organization
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Replication Fork Processing
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To UV
Interstrand Cross-link Repair
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic G2/M Transition Checkpoint
Response To Arsenic-containing Substance
Nuclear Membrane Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Protein Localization To Site Of Double-strand Break
Regulation Of Double-strand Break Repair
Pathways
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Ceralasertib
Diseases
Alveolar rhabdomyosarcoma
Seckel syndrome
GWAS
Heel bone mineral density (
30598549
)
Height (
31562340
)
Waist circumference adjusted for body mass index (
34021172
)
Eosinophil count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
27863252
29403010
32888494
)
Red cell distribution width (
28957414
32888494
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
83 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CCNF
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB1
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
SZRD1P1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
58 interacting genes:
AATF
ABL1
AP1B1
AP3B1
APBB1
ARHGEF1
ATM
BLM
BRCA1
BRCA2
CDKN2C
CEP164
CHD4
CHEK1
CHEK2
CHUK
CLSPN
CREB1
DCAF1
DCLRE1C
DTL
E2F1
E4F1
EEF1E1
EP300
ETAA1
ETV1
FANCA
FANCD2
FANCI
FLT1
H2AX
KDR
LIG4
MCM2
MCPH1
MRE11
MSH2
NBN
NFE2L2
PA2G4
PARP1
PIK3CA
POLD1
POLN
PPP2R3A
RAD17
RASSF1
RHEB
RPA1
TP53
TREX1
UHRF1
UHRF2
UPF1
USP2-AS1
XPA
XRCC5
Entrez ID
1869
545
HPRD ID
01806
08369
Ensembl ID
ENSG00000101412
ENSG00000175054
Uniprot IDs
Q01094
Q9BSD8
Q13535
PDB IDs
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
9CB3
5YZ0
Enriched GO Terms of Interacting Partners
?
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Chromatin Organization
DNA Damage Response
Chromatin Remodeling
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Repair
G1/S Transition Of Mitotic Cell Cycle
DNA Metabolic Process
Cell Cycle G1/S Phase Transition
Chromatin
Cellular Response To Stress
Regulation Of DNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Protein Localization To Site Of Double-strand Break
Positive Regulation Of DNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Programmed Cell Death
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleic Acid Metabolic Process
Double-strand Break Repair
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Chromosome, Telomeric Region
Mitotic DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
DNA Recombination
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Nucleoplasm
Recombinational Repair
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Response To Radiation
Damaged DNA Binding
Double-strand Break Repair Via Homologous Recombination
Mitotic G2/M Transition Checkpoint
Cellular Response To Radiation
Chromosome Organization
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Primary Metabolic Process
Response To Gamma Radiation
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
Mitotic G2 DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA Binding
Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Telomere Maintenance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?