E2F1 and SP2

Number of citations of the paper that reports this interaction (PubMedID 10547281)
0

Data Source:
HPRD (in vivo, in vitro)

		E2F1	SP2
Description		E2F transcription factor 1	Sp2 transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Protein-containing Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding Protein Dimerization Activity Molecular Adaptor Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Checkpoint Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Anoikis Negative Regulation Of DNA Binding Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Regulation Of Cell Cycle Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Fat Cell Proliferation Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Immune Response
Pathways		Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Height ( 31562340) Waist circumference adjusted for body mass index ( 34021172)	Asthma with severe exacerbations ( 32841424) Birth weight ( 27680694) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Childhood body mass index ( 33045005) Hair color ( 29662168)
Interacting Genes		83 interacting genes: ARID3A ATAD2 ATM ATR BIN1 BIRC2 BRCA1 BRD2 BRMS1 BTRC CCNA1 CCNA2 CCNF CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 CUL2 DDB2 DIABLO E2F6 EP300 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM4 MGA MNAT1 MTA1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NFKB1 NPDC1 NRIP1 NSMCE3 PARP1 PHB1 PKIB PRDM2 PURA RARA RB1 RBL1 RNF126 RNF144A SERTAD2 SETD7 SIRT1 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 SZRD1P1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP UBE3A UCHL5 VHL YWHAQ	11 interacting genes: APP BANP CINP E2F1 FHL2 MCM7 NFYC NKX3-1 NRF1 QRICH1 ZDHHC17
Entrez ID		1869	6668
HPRD ID		01806	03481
Ensembl ID		ENSG00000101412	ENSG00000167182
Uniprot IDs		Q01094 Q9BSD8	Q02086
PDB IDs		1H24 1O9K 2AZE 5M9N 5M9O 6G0P 6ULS 9CB3
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Chromatin Organization DNA Damage Response Chromatin Remodeling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Repair G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Cell Cycle G1/S Phase Transition Chromatin Cellular Response To Stress Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of DNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death	DNA Binding Cellular Response To Xenobiotic Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Programmed Cell Death Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Nerve Growth Factor Stimulus Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity Positive Regulation Of Androgen Secretion MADS Box Domain Binding Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Xenobiotic Stimulus Acetylcholine Receptor Activator Activity Response To Interleukin-1 Regulation Of DNA-templated Transcription Response To Growth Factor Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Lipoprotein Particle Positive Regulation Of Protein Import DNA Damage Response Atrial Cardiac Muscle Cell Development Dorsal Aorta Development Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium-mediated Signaling Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Stress
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