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E2F1 and SP3
Number of citations of the paper that reports this interaction (PMID
10547281
)
20
Data Source:
HPRD
(in vitro, in vivo)
E2F1
SP3
Gene Name
E2F transcription factor 1
Sp3 transcription factor
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Rb-E2F Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Plasma Membrane
PML Body
Transcriptional Repressor Complex
Molecular Function
Core Promoter Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
Chromatin Binding
Double-stranded DNA Binding
Protein Binding
Metal Ion Binding
Biological Process
DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Apoptotic Process
Notch Signaling Pathway
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Forebrain Development
Anoikis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Ossification
Natural Killer Cell Differentiation
Trophectodermal Cell Differentiation
Liver Development
Embryonic Placenta Development
Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
B Cell Differentiation
T Cell Differentiation
Megakaryocyte Differentiation
Monocyte Differentiation
Lung Development
Granulocyte Differentiation
Enucleate Erythrocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Embryonic Camera-type Eye Morphogenesis
Embryonic Skeletal System Development
Embryonic Process Involved In Female Pregnancy
Definitive Hemopoiesis
Pathways
Cellular Senescence
Activation of BH3-only proteins
Oncogene Induced Senescence
Assembly of the pre-replicative complex
Pre-NOTCH Transcription and Translation
G2 Phase
G1/S Transition
G1/S-Specific Transcription
Programmed Cell Death
Pre-NOTCH Expression and Processing
Mitotic G1-G1/S phases
Intrinsic Pathway for Apoptosis
E2F mediated regulation of DNA replication
Signaling by NOTCH
DNA Replication Pre-Initiation
G1 Phase
M/G1 Transition
Regulation of DNA replication
G0 and Early G1
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Activation of NOXA and translocation to mitochondria
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
Activation of PUMA and translocation to mitochondria
Association of licensing factors with the pre-replicative complex
Mitotic G2-G2/M phases
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS
Protein-Protein Interactions
70 interactors:
ARID3A
ATAD2
ATM
ATR
BRCA1
BRD2
BTRC
CCNA1
CCNA2
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
DDB2
E2F6
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM2
MDM4
MGA
MNAT1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NDNL2
NFKB1
NPDC1
NRIP1
PARP1
PHB
PKIB
PRDM2
PURA
RARA
RB1
RNF144A
SERTAD2
SETD7
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
VHL
YWHAQ
19 interactors:
E2F1
EP300
ESR1
GABPA
GCH1
GRIN1
HDAC1
HDAC2
HLTF
NKX3-1
PIAS1
RB1
RBBP4
SP1
STK19
SUMO1
TP53
UBE2I
ZBTB7A
Entrez ID
1869
6670
HPRD ID
01806
03483
Ensembl ID
ENSG00000101412
ENSG00000172845
Uniprot IDs
Q01094
Q9BSD8
B7ZLN9
Q02447
Q59FX5
Q86TP0
PDB IDs
1H24
1O9K
2AZE
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Gene Expression
Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Regulation Of Cell Cycle
Negative Regulation Of Biosynthetic Process
Cellular Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Process
Cell Cycle Phase Transition
Cellular Response To DNA Damage Stimulus
Transcription Initiation From RNA Polymerase II Promoter
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Cell Cycle
Mitotic Cell Cycle Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
DNA Repair
Cellular Response To Stress
DNA-templated Transcription, Initiation
Intracellular Steroid Hormone Receptor Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Rhythmic Process
RNA Metabolic Process
Heterocycle Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Regulation Of Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Chromatin Organization
Regulation Of Signaling
Response To Organic Substance
Biosynthetic Process
Cellular Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Signal Transduction
Chromatin Modification
Regulation Of Cell Cycle
Chromatin Remodeling
Intracellular Steroid Hormone Receptor Signaling Pathway
Cellular Response To Organic Substance
Chromosome Organization
Regulation Of Cell Proliferation
Mitotic Cell Cycle
Cellular Response To Hypoxia
Tagcloud
?
box
coexpression
consensus
delays
displaying
dp
dps
e2fs
ectopic
emphasizes
exit
heterodimerization
heterodimers
lacks
members
namely
pocket
possesses
possessing
preference
quiescent
refer
shares
suppresses
transactivational
tttcccgc
tttcgcgc
unlike
Tagcloud (Difference)
?
box
coexpression
consensus
delays
displaying
dp
dps
e2fs
ectopic
emphasizes
exit
heterodimerization
heterodimers
lacks
members
namely
pocket
possesses
possessing
preference
quiescent
refer
shares
suppresses
transactivational
tttcccgc
tttcgcgc
unlike
Tagcloud (Intersection)
?