E2F1 and NDN

Number of citations of the paper that reports this interaction (PMID 9422723)
30

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		E2F1	NDN
Gene Name		E2F transcription factor 1	necdin, melanoma antigen (MAGE) family member
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Rb-E2F Complex	Nucleus Centrosome Cytosol Cell Projection Perikaryon
	Molecular Function	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	DNA Binding Gamma-tubulin Binding
	Biological Process	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Notch Signaling Pathway Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Anoikis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Cellular Response To Fatty Acid Cellular Response To Hypoxia Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	Neuron Migration Respiratory System Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Axonal Fasciculation Central Nervous System Development Negative Regulation Of Cell Proliferation Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Axon Extension Multicellular Organismal Homeostasis Genetic Imprinting
Pathways		Cellular Senescence Activation of BH3-only proteins Oncogene Induced Senescence Assembly of the pre-replicative complex Pre-NOTCH Transcription and Translation G2 Phase G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase M/G1 Transition Regulation of DNA replication G0 and Early G1 CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS
Protein-Protein Interactions		70 interactors: ARID3A ATAD2 ATM ATR BRCA1 BRD2 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 DDB2 E2F6 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NDNL2 NFKB1 NPDC1 NRIP1 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RNF144A SERTAD2 SETD7 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP VHL YWHAQ	43 interactors: APBB1IP ARSE BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 LAX1 LPXN MIER2 MKRN2 MPP6 N6AMT2 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PJA1 PPFIA1 SERTAD3 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B
Entrez ID		1869	4692
HPRD ID		01806	03667
Ensembl ID		ENSG00000101412	ENSG00000182636
Uniprot IDs		Q01094 Q9BSD8	Q99608
PDB IDs		1H24 1O9K 2AZE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Process Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process DNA Repair Cellular Response To Stress DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle	Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Anterograde Axon Cargo Transport Regulation Of Fibroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels RNA Metabolic Process Cellular Response To Oxygen Levels Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Gene Expression Response To Wounding Regulation Of Gene Expression Transcription, DNA-templated Microtubule-based Movement RNA Biosynthetic Process Cellular Localization Positive Regulation Of Fibroblast Proliferation Circadian Rhythm MRNA Transcription From RNA Polymerase II Promoter Cell Differentiation Wound Healing Regulation Of Thymocyte Apoptotic Process MRNA Transcription Transcription From RNA Polymerase II Promoter Developmental Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Anterograde Synaptic Vesicle Transport Regulation Of Establishment Of Protein Localization Establishment Of Localization In Cell Positive Regulation Of Natural Killer Cell Activation Melanosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Pigment Granule Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Embryonic Placenta Development Regulation Of Cellular Localization Tissue Remodeling Iron Ion Homeostasis MRNA Stabilization Cell Morphogenesis Microtubule-based Process Anatomical Structure Development
Tagcloud ?		box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike	biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1
Tagcloud (Difference) ?		box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike	biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1
Tagcloud (Intersection) ?