CENPE and BUB1B

Number of citations of the paper that reports this interaction (PMID 10477750)
82

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		CENPE	BUB1B
Gene Name		centromere protein E, 312kDa	BUB1 mitotic checkpoint serine/threonine kinase B
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome, Centromeric Region Condensed Chromosome Outer Kinetochore Nucleus Chromosome Cytoplasm Cytosol Kinesin Complex Microtubule Microtubule Cytoskeleton Membrane Midbody Mitotic Spindle Midzone	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Cytosol Perinuclear Region Of Cytoplasm Spindle Midzone
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity Kinetochore Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Multicellular Organismal Development Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Kinetochore Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System	Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		10 interactors: BUB1B CENPF CUL1 DNAJB1 FANCA NUF2 SEPT7 SKP1 TRAF4 UBC	21 interactors: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB1 BUB3 CASC5 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FZR1 HDAC1 MAP3K4 SNCG TP73
Entrez ID		1062	701
HPRD ID		00316	04176
Ensembl ID		ENSG00000138778	ENSG00000156970
Uniprot IDs		Q02224	O60566
PDB IDs		1T5C	2WVI 3SI5 4GGD
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Division Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Circadian Rhythm SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Spindle Checkpoint	Spindle Assembly Checkpoint Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Cell Cycle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Cell Division Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Cell Division Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		ags aurka aurkb bop1 bub1 bub1b ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a deoxyribonucleotides earliest foxm1 illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic psrc1 rrm1 segregation transcriptomic	accompanying bubr1 deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle
Tagcloud (Difference) ?		ags aurka aurkb bop1 bub1 ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a deoxyribonucleotides earliest foxm1 illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic psrc1 rrm1 segregation transcriptomic	accompanying bubr1 deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle
Tagcloud (Intersection) ?		bub1b