CENPE and FANCA

Number of citations of the paper that reports this interaction (PubMedID 19779646)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CENPE	FANCA
Description		centromere protein E	FA complementation group A
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Spindle Midzone Mitotic Spindle Mitotic Spindle Midzone	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Kinetochore Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Nuclear Division Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins	Fanconi Anemia Pathway PKR-mediated signaling
Drugs		GSK-923295
Diseases			Fanconi anemia
GWAS		Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 23666240 25877299 28604728 28604732)	Brain morphology (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 30054594 31959993) Low tan response ( 29739929) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)
Interacting Genes		13 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC USP7	47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		1062	2175
HPRD ID		00316	06186
Ensembl ID		ENSG00000138778	ENSG00000187741
Uniprot IDs		Q02224	O15360 Q0VAP4
PDB IDs		1T5C 5JVP 6M4I 8HFH 8OWI 8WHL	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Chromosome, Centromeric Region Kinetochore Regulation Of Mitotic Sister Chromatid Separation TORC1 Signaling Ubiquitin Ligase Complex Scaffold Activity Nucleus Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization Cytosol TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Autophagosome Assembly Regulation Of TORC1 Signaling Autophagosome Organization Regulation Of Sister Chromatid Segregation Kinetochore Organization Negative Regulation Of Autophagy Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Apoptotic Process Chromosome Regulation Of Chromosome Segregation Organelle Assembly Regulation Of Nuclear Division Regulation Of TOR Signaling Organelle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Vacuole Organization Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Spindle Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Nucleoplasm SCF Ubiquitin Ligase Complex Protein Ubiquitination Negative Regulation Of Cell Cycle Process Negative Regulation Of TORC1 Signaling Regulation Of Embryonic Cell Shape Ubiquitin Protein Ligase Binding Intracellular Signal Transduction Regulation Of Organelle Organization	Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus
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