CENPE and CENPF

Number of citations of the paper that reports this interaction (PMID 9763420)
63

Data Source:
HPRD (two hybrid)

		CENPE	CENPF
Gene Name		centromere protein E, 312kDa	centromere protein F, 350/400kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome, Centromeric Region Condensed Chromosome Outer Kinetochore Nucleus Chromosome Cytoplasm Cytosol Kinesin Complex Microtubule Microtubule Cytoskeleton Membrane Midbody Mitotic Spindle Midzone	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Spindle Cytosol Nuclear Matrix Midbody Pronucleus Perinuclear Region Of Cytoplasm
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity Kinetochore Binding	Chromatin Binding Protein Binding Protein C-terminus Binding Transcription Factor Binding Protein Homodimerization Activity Dynein Binding
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Multicellular Organismal Development Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Muscle Organ Development Cell Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Cell Differentiation Response To Drug Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly Regulation Of Cell Cycle DNA Biosynthetic Process
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion G2/M Transition Mitotic Anaphase Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Polo-like kinase mediated events Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666240)	Response to antineoplastic agents ( 21659360)
Protein-Protein Interactions		10 interactors: BUB1B CENPF CUL1 DNAJB1 FANCA NUF2 SEPT7 SKP1 TRAF4 UBC	10 interactors: BRAP CENPE CHMP2B FNTA FNTB NDEL1 NUP133 SNAP25 SVIL TOP3B
Entrez ID		1062	1063
HPRD ID		00316	02582
Ensembl ID		ENSG00000138778	ENSG00000117724
Uniprot IDs		Q02224	P49454
PDB IDs		1T5C
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Division Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Circadian Rhythm SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Spindle Checkpoint	Establishment Of Chromosome Localization Protein Farnesylation Chromosome Segregation Establishment Of Organelle Localization Nucleus Organization Protein Prenylation Organelle Localization Regulation Of Cell Cycle Regulation Of Rhodopsin Mediated Signaling Pathway Mitotic Metaphase Plate Congression Organelle Organization Rhodopsin Mediated Signaling Pathway Metaphase Plate Congression Nuclear Envelope Disassembly Mitotic Cell Cycle Process Regulation Of Cell Division Mitotic Cell Cycle Positive Regulation Of Cell Cycle Mitotic Nuclear Division Membrane Organization Nuclear Envelope Organization Cellular Protein Complex Assembly Positive Regulation Of Tubulin Deacetylation Phototransduction, Visible Light Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Establishment Of Localization In Cell Detection Of Light Stimulus Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Mitotic Chromosome Movement Towards Spindle Pole Cellular Response To Radiation Cell Cycle Wound Healing Cellular Localization Cellular Macromolecular Complex Assembly Regulation Of Tubulin Deacetylation Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Positive Regulation Of Axon Regeneration Positive Regulation Of Deacetylase Activity Response To Wounding Retrograde Axon Cargo Transport Viral Budding Via Host ESCRT Complex Viral Life Cycle
Tagcloud ?		ags aurka aurkb bop1 bub1 bub1b ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a deoxyribonucleotides earliest foxm1 illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic psrc1 rrm1 segregation transcriptomic	assembled causal computational coordinated cross drivers engineered foxm1 genetically genome indicator interactomes interrogation malignancy master networks profiles promote prostate regulators regulatory represents robust shows synergistic synergistically validation valuable wide
Tagcloud (Difference) ?		ags aurka aurkb bop1 bub1 bub1b ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a deoxyribonucleotides earliest illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic psrc1 rrm1 segregation transcriptomic	assembled causal computational coordinated cross drivers engineered genetically genome indicator interactomes interrogation malignancy master networks profiles promote prostate regulators regulatory represents robust shows synergistic synergistically validation valuable wide
Tagcloud (Intersection) ?		foxm1