CENPE and DUX1

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (two hybrid)

		CENPE	DUX1
Description		centromere protein E	double homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Spindle Midzone Mitotic Spindle Mitotic Spindle Midzone	Nucleus
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Kinetochore Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cell Cycle Nuclear Division Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs		GSK-923295
Diseases
GWAS		Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 23666240 25877299 28604728 28604732)
Interacting Genes		13 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC USP7	5 interacting genes: ACTN2 ACTN3 CENPE CSNK2B DES
Entrez ID		1062	26584
HPRD ID		00316	10609
Ensembl ID		ENSG00000138778
Uniprot IDs		Q02224	O43812
PDB IDs		1T5C 5JVP 6M4I 8HFH 8OWI 8WHL
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Chromosome, Centromeric Region Kinetochore Regulation Of Mitotic Sister Chromatid Separation TORC1 Signaling Ubiquitin Ligase Complex Scaffold Activity Nucleus Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization Cytosol TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Autophagosome Assembly Regulation Of TORC1 Signaling Autophagosome Organization Regulation Of Sister Chromatid Segregation Kinetochore Organization Negative Regulation Of Autophagy Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Apoptotic Process Chromosome Regulation Of Chromosome Segregation Organelle Assembly Regulation Of Nuclear Division Regulation Of TOR Signaling Organelle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Vacuole Organization Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Spindle Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Nucleoplasm SCF Ubiquitin Ligase Complex Protein Ubiquitination Negative Regulation Of Cell Cycle Process Negative Regulation Of TORC1 Signaling Regulation Of Embryonic Cell Shape Ubiquitin Protein Ligase Binding Intracellular Signal Transduction Regulation Of Organelle Organization	Z Disc Pseudopodium Focal Adhesion Assembly Structural Constituent Of Muscle Cell-substrate Junction Organization Cytoskeleton Organization Cell-substrate Junction Assembly Sarcomere Cortical Actin Cytoskeleton Cytoskeletal Protein Binding Actin Filament Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Muscle Cell Development Titin Z Domain Binding Identical Protein Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Transmembrane Transporter Binding Integrin Binding Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Extracellular Exosome Microspike Assembly Mitotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Endocytic Recycling Organelle Organization Actin Filament Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Protein Domain Specific Binding Cell Junction Assembly Cell Junction Channel Activator Activity FATZ Binding Cellular Component Assembly LIM Domain Binding Negative Regulation Of Relaxation Of Muscle Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle System Process Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation
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