CENPE

Description		centromere protein E
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Spindle Midzone Mitotic Spindle Mitotic Spindle Midzone
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Kinetochore Binding
	Biological Process	Mitotic Cell Cycle Nuclear Division Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs		GSK-923295
Diseases
GWAS		Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 23666240 25877299 28604728 28604732)
Novel Interacting Genes		1 novel interacting genes: RHEB
Interacting Genes		13 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC USP7
Entrez ID		1062
HPRD ID		00316
Ensembl ID		ENSG00000138778
Uniprot IDs		Q02224
PDB IDs		1T5C 5JVP 6M4I 8HFH 8OWI 8WHL
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Chromosome, Centromeric Region Kinetochore Regulation Of Mitotic Sister Chromatid Separation TORC1 Signaling Ubiquitin Ligase Complex Scaffold Activity Nucleus Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization Cytosol TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Autophagosome Assembly Regulation Of TORC1 Signaling Autophagosome Organization Regulation Of Sister Chromatid Segregation Kinetochore Organization Negative Regulation Of Autophagy Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Apoptotic Process Chromosome Regulation Of Chromosome Segregation Organelle Assembly Regulation Of Nuclear Division Regulation Of TOR Signaling Organelle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Vacuole Organization Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Spindle Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Nucleoplasm SCF Ubiquitin Ligase Complex Protein Ubiquitination Negative Regulation Of Cell Cycle Process Negative Regulation Of TORC1 Signaling Regulation Of Embryonic Cell Shape Ubiquitin Protein Ligase Binding Intracellular Signal Transduction Regulation Of Organelle Organization
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