CENPE and NUF2

Number of citations of the paper that reports this interaction (PMID 19779646)
0

Data Source:
BioGRID (two hybrid)

		CENPE	NUF2
Gene Name		centromere protein E, 312kDa	NUF2, NDC80 kinetochore complex component
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Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome, Centromeric Region Condensed Chromosome Outer Kinetochore Nucleus Chromosome Cytoplasm Cytosol Kinesin Complex Microtubule Microtubule Cytoskeleton Membrane Midbody Mitotic Spindle Midzone	Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity Kinetochore Binding	Molecular_function Protein Binding
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Multicellular Organismal Development Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		10 interactors: BUB1B CENPF CUL1 DNAJB1 FANCA NUF2 SEPT7 SKP1 TRAF4 UBC	10 interactors: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 SDCBP2
Entrez ID		1062	83540
HPRD ID		00316	10817
Ensembl ID		ENSG00000138778	ENSG00000143228
Uniprot IDs		Q02224	Q9BZD4
PDB IDs		1T5C	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Division Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Circadian Rhythm SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Spindle Checkpoint	Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Organization Spindle Stabilization Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Anchoring Mitotic Nuclear Division Mitotic Cell Cycle Microtubule-based Process Cellular Localization Histone-serine Phosphorylation Spindle Organization Organelle Localization Cell Division Microtubule Cytoskeleton Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Organelle Assembly Chromosome Organization Kinetochore Assembly Maintenance Of Location In Cell Protein Localization Cytoskeleton Organization Organelle Organization Kinetochore Organization Histone Phosphorylation Negative Regulation Of Microtubule Depolymerization Chromosome Segregation Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Division Centromere Complex Assembly Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cytokinesis Negative Regulation Of Protein Binding Establishment Of Organelle Localization Cellular Protein Complex Assembly Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Mitotic Sister Chromatid Segregation Spindle Assembly Protein Complex Assembly Sister Chromatid Segregation Cell Cycle Process Negative Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Cell Cycle Process Regulation Of Protein Depolymerization
Tagcloud ?		ags aurka aurkb bop1 bub1 bub1b ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a deoxyribonucleotides earliest foxm1 illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic psrc1 rrm1 segregation transcriptomic	ams2 ams2p bioinformatics cenpa centromere centromeres centromeric cnp1 cnp1p defining disrupted gata identifies incorporation kinetochore linker mal2 microarrays mis12 mis18 nucleosome nucleosomes participating pombe positioned positioning regularly schizosaccharomyces tiling
Tagcloud (Difference) ?		ags aurka aurkb bop1 bub1 bub1b ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a deoxyribonucleotides earliest foxm1 illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic psrc1 rrm1 segregation transcriptomic	ams2 ams2p bioinformatics cenpa centromere centromeres centromeric cnp1 cnp1p defining disrupted gata identifies incorporation kinetochore linker mal2 microarrays mis12 mis18 nucleosome nucleosomes participating pombe positioned positioning regularly schizosaccharomyces tiling
Tagcloud (Intersection) ?